Gene interactions and pathways from curated databases and text-mining

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CRK — TNFSF11

Text-mined interactions from Literome

Takada et al., Blood 2004 : Deletion of both TNF receptors also potentiated RANKL induced c-Jun N-terminal kinase (JNK), extracellular signal regulated kinase 1 and 2 ( ERK1/2 ), and p38 mitogen activated protein kinase ( MAPK ) activations in a dose- and time dependent manner
Mori et al., J Pathol 2007 (Bone Neoplasms...) : Thus, RANKL significantly induced the phosphorylation of ERK1/2, p38 and IkappaB in RANK positive osteosarcoma cells
Pi et al., J Periodontal Res 2007 : Additional experiments revealed that heme oxygenase-1 inducer (hemin), a membrane-permeable cGMP analog ( 8-bromo-cGMP ), carbon monoxide, extracellular signal regulated kinase, p38 mitogen activated protein kinase inhibitor, protein kinase inhibitor ( KT5823 ), and nuclear factor-kappaB inhibitor ( pyrrolidine dithiocarbamate ) also blocked the effects of H2O2 on cell viability and RANKL mRNA expression in periodontal ligament cells
Kalliolias et al., Arthritis Rheum 2010 (Arthritis, Rheumatoid...) : IL-27 inhibited human osteoclastogenesis, suppressed the induction of NFATc1, down-regulated the expression of RANK and triggering receptor expressed on myeloid cells 2 ( TREM-2 ), and inhibited RANKL mediated activation of ERK, p38 , and NF-kappaB in osteoclast precursors
Nepal et al., Eur J Pharmacol 2013 : Hispidulin was found to inhibit RANKL induced activation of Jun N-terminal kinase (JNK) and p38 , in addition to NF-?B in vitro experiment