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CRK — TNFSF11
Text-mined interactions from Literome
Takada et al., Blood 2004
:
Deletion of both TNF receptors also potentiated
RANKL induced c-Jun N-terminal kinase (JNK), extracellular signal regulated kinase 1 and 2 ( ERK1/2 ), and
p38 mitogen activated protein kinase ( MAPK ) activations in a dose- and time dependent manner
Mori et al., J Pathol 2007
(Bone Neoplasms...) :
Thus,
RANKL significantly
induced the phosphorylation of ERK1/2,
p38 and IkappaB in RANK positive osteosarcoma cells
Pi et al., J Periodontal Res 2007
:
Additional experiments revealed that heme oxygenase-1 inducer (hemin), a membrane-permeable cGMP analog ( 8-bromo-cGMP ), carbon monoxide, extracellular signal regulated kinase,
p38 mitogen activated protein kinase inhibitor, protein kinase inhibitor ( KT5823 ), and nuclear factor-kappaB inhibitor ( pyrrolidine dithiocarbamate ) also
blocked the effects of H2O2 on cell viability and
RANKL mRNA expression in periodontal ligament cells
Kalliolias et al., Arthritis Rheum 2010
(Arthritis, Rheumatoid...) :
IL-27 inhibited human osteoclastogenesis, suppressed the induction of NFATc1, down-regulated the expression of RANK and triggering receptor expressed on myeloid cells 2 ( TREM-2 ), and inhibited
RANKL mediated
activation of ERK,
p38 , and NF-kappaB in osteoclast precursors
Nepal et al., Eur J Pharmacol 2013
:
Hispidulin was found to inhibit
RANKL induced activation of Jun N-terminal kinase (JNK) and
p38 , in addition to NF-?B in vitro experiment