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SP1 — TNFSF10

Text-mined interactions from Literome

Xu et al., Cancer Res 2008 (Breast Neoplasms) : Sp1 mediated TRAIL induction in chemosensitization ... Using different reporter constructs in conjunction with transcription activity assays and chromatin immunoprecipitation assays, we provide evidence that the transcription factor Sp1 is responsible for TRAIL induction by MS275 alone or in combination with Adriamycin ... Taken together, our results indicate that induction of TRAIL by the combined treatments with MS275 and Adriamycin is mediated by Sp1 and suggest that transcription factor Sp1 is an important target for the development of novel anticancer agents
Chan et al., Circ Res 2010 : Mutational studies confirmed a role for Sp1 in injury- and FGF-2-inducible TRAIL transcription ... Conclusions : We conclude that TRAIL induction involves FGF-2, Sp1-phosphorylation and NFkappaB and that TRAIL promotes VSMC proliferation and neointima formation after arterial injury
Wang et al., PloS one 2011 : Knockdown of NFATc1 increased Sp1 transcription factor binding to the TRAIL promoter and, importantly, inhibition of Sp1 , by chemical inhibition or RNA interference, increased TRAIL expression ... These studies identify a novel mechanism for TRAIL regulation by which activation of NFATc1 increases TRAIL expression through negative regulation of Sp1 binding to the TRAIL promoter