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FOXO3 — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
You et al., Proc Natl Acad Sci U S A 2004
:
p53 dependent inhibition of
FKHRL1 in response to DNA damage through protein kinase SGK1 ... In response to DNA damage,
p53 activation
led to
FKHRL1 phosphorylation and subcellular localization change, which resulted in inhibition of FKHRL1 transcription activity ... AKT was dispensable for
p53 dependent suppression of
FKHRL1
You et al., Proc Natl Acad Sci U S A 2006
:
Here we show that nuclear, activated
FOXO3a could
impair p53 transcriptional activity ... Furthermore,
FOXO3a could
promote p53 cytoplasmic accumulation by increasing its association with nuclear exporting machinery
Zou et al., Endocrinology 2009
(Pheochromocytoma) :
The dephosphorylation of Akt resulted in increased expression of a proapoptotic protein,
p53 up-regulated modulator of apoptosis ( PUMA ), in a
forkhead box O3a dependent manner
Fu et al., J Biol Chem 2009
:
In cells stably expressing a temperature-sensitive p53 mutant, activation of
p53 by shifting to permissive temperatures
leads to MDM2 induction and degradation of endogenous
FOXO3A
Kurinna et al., Hepatology 2010
(Carcinoma, Hepatocellular...) :
Direct
activation of
forkhead box O3 by tumor suppressors
p53 and p73 is disrupted during liver regeneration in mice
Renault et al., Oncogene 2011
:
Here, we show that
p53 regulates the expression of
FoxO3 , one of the four mammalian FoxO genes, in response to DNA damaging agents in both mouse embryonic fibroblasts and thymocytes
Chung et al., Nature communications 2012
:
FOXO3 is essential for DNA damage induced apoptosis and conversely FOXO3
requires ATM, Chk2 and phosphorylated
p53 isoforms to trigger apoptosis as a result of DNA damage