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CCND1 — E2F8
Text-mined interactions from Literome
Lee et al., Mol Cell Biol 2000
(Cell Transformation, Neoplastic...) :
NeuT induction of the
cyclin D1 promoter
required the
E2F and Sp1 DNA binding sites and was inhibited by dominant negative E2F-1 or DP-1
Beier et al., Mol Biol Cell 2001
:
Inhibition of
cyclin D1 expression with antisense oligonucleotides causes a delay in progression of chondrocytes through the G1 phase of the cell cycle,
reduced E2F activity, and decreased proliferation
Dai et al., Cell cycle (Georgetown, Tex.) 2006
(Multiple Myeloma) :
In pRb-null U266 cells, enforced overexpression of
cyclin D1 diminished CDK inhibitor mediated dephosphorylation of the pocket proteins p130 and p107, reduced binding of E2F1 and E2F4 to p130 and p107, and
attenuated inhibition of
E2F activity
Schulze et al., Oncogene 1994
:
Activation of the
E2F transcription factor by
cyclin D1 is blocked by p16INK4, the product of the putative tumor suppressor gene MTS1 ... The data reported here support a direct
role for
cyclin D1 and its associated kinase in cell cycle regulation of
E2F activity and S phase-specific gene expression
Watanabe et al., Mol Cell Biol 1998
:
Inhibition of cyclin D1 kinase activity is associated with
E2F mediated inhibition of
cyclin D1 promoter activity through E2F and Sp1 ... In contrast with E2F-1,
E2F-4 induced
cyclin D1 promoter activity