Gabryel et al., Pharmacol Rep 2011
(Inflammation...) :
Our data suggest that HMGB1 release may be partly an active process triggered by oxidative stress because the antioxidant N-acetylcysteine (NAC) clearly attenuated HMGB1 expression and release
Zhang et al., Autophagy 2011
:
In response to stress such as therapeutic insults, NAC1 increases the expression, cytosolic translocation and release of HMGB1 ; elevated level of the cytoplasmic HMGB1 leads to activation of autophagy