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IGF1 — LEPR

Text-mined interactions from Literome

Garofalo et al., Clin Cancer Res 2006 (Breast Neoplasms...) : The effects of insulin, IGF-I , estradiol, and hypoxia on leptin and ObR mRNA expression were assessed by reverse transcription-PCR in MCF-7 and MDA-MB-231 breast cancer cell lines
Gregoraszczuk et al., Acta Vet Hung 2006 : Both GH and IGF-I increased leptin receptor expression in prepubertal pig ovaries
Gregoraszczuk et al., J Reprod Dev 2007 : Moreover, this data points to an important role of IGF-I in leptin receptor expression during the entire estrous cycle, with a special role during the prepubertal period
Ozbay et al., Mol Cancer Res 2008 (Breast Neoplasms) : Stimulation of cells with IGF-I promoted Ob-R phosphorylation, which was blocked by IGF-IR kinase inhibition
Saxena et al., Cancer Res 2008 (Breast Neoplasms...) : We found a novel bidirectional crosstalk between leptin and IGF-I signaling ; IGF-I induced phosphorylation of leptin receptor ( Ob-Rb ) and leptin induced phosphorylation of IGF-I receptor (IGF-IR), whereas cotreatment induced synergistic phosphorylation and association of Ob-Rb and IGF-IR along with activation of downstream effectors, Akt and extracellular signal regulated kinase ... We found a novel bidirectional crosstalk between leptin and IGF-I signaling ; IGF-I induced phosphorylation of leptin receptor ( Ob-Rb ) and leptin induced phosphorylation of IGF-I receptor (IGF-IR), whereas cotreatment induced synergistic phosphorylation and association of Ob-Rb and IGF-IR along with activation of downstream effectors, Akt and extracellular signal regulated kinase
Ramsay et al., Comp Biochem Physiol B Biochem Mol Biol 2010 : IGF-I mediated inhibition of leptin receptor expression in porcine hepatocytes