Gene interactions and pathways from curated databases and text-mining

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TNF — TRAF1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Carpentier et al., FEBS Lett 1999 : Here we demonstrate that expression of TRAF1 is induced by TNF and the protein kinase C ( PKC ) activator PMA, but not by interleukin-1 (IL-1) ... TNF induced upregulation of TRAF1 could be prevented by pretreatment of the cells with the proteasome inhibitor MG-132, whereas the PKC inhibitor Ro31-8220 was without effect
Pryhuber et al., Am J Respir Cell Mol Biol 2000 (Pneumonia) : Tumor necrosis factor-alpha induced lung cell expression of antiapoptotic genes TRAF1 and cIAP2 ... We demonstrate for the first time TNF-alpha dose dependent induction of TRAF1 protein and messenger RNA ( mRNA ) in human H441 and A549 pulmonary adenocarcinoma cell lines, as well as in lung cells of C57BL/6J mice after intratracheal administration of TNF-alpha ... In contrast to the epithelial cells, TRAF1 was not induced by TNF-alpha in U937 cells, a human monocytic cell line, suggesting cell type-specific regulation
Nolan et al., Shock 2000 : These data demonstrate that inhibition of PMN apoptosis and TRAF-1 induction by LPS and TNFalpha is NF-kappaB dependent
Caunt et al., J Biol Chem 2001 : Ras controls tumor necrosis factor receptor associated factor ( TRAF)6 dependent induction of nuclear factor-kappa b. Selective regulation through receptor signaling components
Aota et al., Exp Cell Res 2002 : Our results, therefore, suggest that one of the mechanisms by which cells acquire resistance to TNF-alpha induced apoptosis is a TNF-alpha induction of TRAF-1
Yang et al., Invest Ophthalmol Vis Sci 2005 : TRAF-1 , c-FLIP, and to a lesser extent c-IAP2 protein levels were increased by TNF-alpha in a time dependent manner, whereas c-IAP1, survivin, Bcl-x ( L ), and TRAF-2 protein levels were not influenced by TNF-alpha treatment at any time point tested ... Overexpression of mutant IkappaB blocked TNF-alpha induced TRAF-1 , TRAF-2, c-IAP1, c-IAP2, c-FLIP, and A1 gene expression and downregulated TRAF-1 protein levels
Shi et al., Immunol Cell Biol 2006 : In contrast, sTNF-alpha stimulated the expression of TRAF1 and TRAF2, recruiting both molecules onto the cell membrane poststimulation
Du et al., Cancer Res 2009 (Neoplasms) : Furthermore, SW480 cells stably transformed with wild-type adenomatous polyposis coli showed decreased beta-catenin protein and increased TNFalpha induced p65 NF-kappaB binding as well as iNOS and Traf1 expression
Min et al., J Immunol 1997 : These data suggest that TNF activates parallel TRAF-NF-kappa B and TRAF-RAC/CDC42-JNK-c-Jun/ATF2 pathways to initiate E-selectin transcription