Gene interactions and pathways from curated databases and text-mining

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HIF1AN — NOTCH1

Text-mined interactions from Literome

Zheng et al., Proc Natl Acad Sci U S A 2008 (Anoxia) : FIH-1 negatively regulates Notch activity and accelerates myogenic differentiation
Lawton et al., Oxidative medicine and cellular longevity 2010 : We found that : 1 ) AAH, HIF-1a, and neuronal migration were stimulated by H2O2; 2 ) si-HIF-1a reduced AAH expression and cell motility ; 3 ) si-AAH inhibited Notch and cell migration, but not HIF-1a ; and 4 ) si-Notch-1 increased FIH and inhibited HIF-1a
Peng et al., Proc Natl Acad Sci U S A 2012 (Psoriasis) : Loss of FIH-1 in vivo increased Notch activity in the limbal epithelium, resulting in a more differentiated phenotype