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CYP19A1 — POR

Text-mined interactions from Literome

Fukami et al., J Clin Endocrinol Metab 2005 (Abnormalities, Multiple...) : The results suggest that Antley-Bixler syndrome with abnormal genitalia and/or impaired steroidogenesis is caused by POR mutations, and that clinical features are variable and primarily explained by impaired activities of POR dependent CYP51A1, CYP17A1, CYP21A2, and CYP19A1
Inaoka et al., Reproductive biology and endocrinology : RB&E 2008 : The expression of mutant POR proteins ( R457H or V492E ), such as those found in ABS patients, had much less effect on aromatase activity than expression of wild-type POR proteins ... Knockdown of endogenous POR protein in KGN human granulosa cells led to reduced estrone production, indicating that endogenous POR affected aromatase activity