Gene interactions and pathways from curated databases and text-mining

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E2F1 — HDAC1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Nicolas et al., J Biol Chem 2000 (Retinoblastoma) : Finally, we found that E2F1 and RbAp48 are physically associated in the presence of Rb and HDAC1 , suggesting that RbAp48 could be involved in transcriptional repression of E2F-responsive genes
Boutillier et al., J Neurochem 2003 : Taken together, our results suggest that, in neuroprotective conditions, histone deacetylase activity allows a constitutive repression of the e2f-1 gene in mature neurones in order to ensure survival
Joshi et al., Biochem Biophys Res Commun 2003 (Breast Neoplasms) : Like full-length prohibitin, the coiled-coil domain also recruited histone deacetylase 1 to repress E2F1
Hlaing et al., J Biol Chem 2004 (Hypertrophy) : We demonstrated previously that angiotensin II stimulates hypertrophy in C2C12 myoblasts by transient activation of the cyclin dependent kinase 4 complex, subsequent phosphorylation of retinoblastoma protein, release of histone deacetylase 1 from the retinoblastoma protein inhibitory complex, and partial activation of the transcription factor E2F-1
Zhang et al., Nucleic Acids Res 2005 : The ErbB3 binding protein Ebp1 interacts with Sin3A to repress E2F1 and AR-mediated transcription ... Functionally, Sin3A enhanced the ability of Ebp1 to repress transcription of androgen receptor (AR) and E2F1 regulated genes
Duan et al., Prostate 2013 (Prostatic Neoplasms) : While androgen suppresses EZH2 in CRPC cells, in LNCaP cells, physiological concentrations of androgen stimulate expression of PRC2 genes ( EZH2, SUZ12, and EED ), which is mediated by androgen induced ANCCA and involves E2F and histone H3K4me3 methylase MLL1 complex