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FSHB — SMAD3
Text-mined interactions from Literome
Suszko et al., Mol Endocrinol 2003
:
Transfection of
Smad3 , but not the highly related Smad2,
led to a ligand independent stimulation of the
FSHbeta promoter activity
Bernard et al., Mol Endocrinol 2004
:
Because SMAD7 functions by preventing access of SMAD2 and SMAD3 to ALK4, these data suggested that both activins and ALK4
require SMAD2 and/or
SMAD3 to affect
FSHbeta transcription ... Transient transfection of
SMAD3 , but not SMADs 1, 2, 4, 5, or 8,
stimulated endogenous
FSHbeta mRNA levels ... To assess more directly
roles for both SMAD2 and
SMAD3 in activin stimulated
FSHbeta expression, RNA interference was used to decrease endogenous SMAD protein levels in LbetaT2 cells
Gregory et al., Mol Endocrinol 2005
(MAP Kinase Signaling System) :
Overexpression of
SMAD3 ( mediator of decapentaplegic related protein 3 ), but not of SMAD2,
increased transcriptional activation of the rat ( r )
FSHbeta gene promoter, which was further enhanced by the combined overexpression of SMAD3 and 4 ( 3+4 )
Suszko et al., Mol Endocrinol 2005
:
We investigated whether these structural features contribute to differential
FSH(beta) transactivation by Smad2 and
Smad3
Bernard et al., Reproductive biology and endocrinology : RB&E 2006
:
Transfection of both ALK4 ( TD ) and ALK7 ( TD ) stimulated
Smad2/3 phosphorylation, and the effects of both receptors on
Fshb promoter activity were
inhibited by depletion of endogenous Smad3 protein levels
McGillivray et al., Endocrinology 2007
:
In addition, the glucocorticoid receptor and
Smad3 are
sufficient to confer a striking synergy with glucocorticoids on the mouse
FSHbeta promoter
Thackray et al., Endocrinology 2008
:
Disruption of
Smad binding to the promoter with a Smad protein lacking the DNA binding domain or an FSHbeta promoter containing mutated activin-response elements
prevents the synergistic enhancement of
FSHbeta transcription
Lamba et al., Endocrinology 2008
:
Both PITX1 and PITX2C interacted with Smad3 ( an effector of the activin signaling cascade in these cells ) in coprecipitation experiments, and the PITX binding site mutation greatly inhibited
Smad2/3/4 stimulated
Fshb transcription