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F2RL1 — RELA
Text-mined interactions from Literome
Bretschneider et al., Br J Pharmacol 1999
:
Activation of
NFkappaB via either PAR-1 or
PAR-2 does not predict mitogenesis
Buddenkotte et al., J Invest Dermatol 2005
(Dermatitis, Atopic) :
Electrophoretic mobility shift assays and morphological transduction studies revealed
PAR2 induced activation and translocation of
nuclear factor kappa B (NF-kappaB) in primary human KTC with a maximum after 1 h. Supershift analysis demonstrated acivation of the p50/p65 heterodimer complex
Fyfe et al., Cytokine 2005
(Inflammation...) :
Unlike IL-1beta,
PAR-2 stimulation did not
activate NF-kappaB , which may explain the lack of IL-8 expression
Syeda et al., J Biol Chem 2006
:
Activation of PAR-1 or
PAR-2 promoted nuclear translocation and phosphorylation of p65-NF-kappaB, and thrombin induced but not PAR-2 induced
p65-NF-kappaB phosphorylation was
reduced by inhibition of MEK or p38MAPK
Goon Goh et al., Cell Signal 2008
:
Overall these novel data demonstrate an IKK2 dependent, predominantly G-protein independent pathway involved in
PAR-2 regulation of
NFkappaB phosphorylation in keratinocytes
Rallabhandi et al., J Biol Chem 2008
(Inflammation) :
In the absence of TLR4,
PAR2 induced
NF-kappaB activity was inhibited by dominant negative ( DN ) -TRIF or DN-TRAM constructs, but not by DN-MyD88, findings confirmed using cell-permeable, adapter-specific BB loop blocking peptides ... Co-expression of TLR4/MD-2/CD14 with
PAR2 in HEK293T cells
led to a synergistic increase in AP-induced
NF-kappaB signaling that was MyD88 dependent and required a functional TLR4, despite the fact that AP exhibited no TLR4 agonist activity
Goh et al., Br J Pharmacol 2009
:
Pretreatment with K-14585 inhibited
PAR(2) mediated p65 NFkappaB phosphorylation and
NFkappaB-DNA binding