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CA2 — GPI

Text-mined interactions from Literome

Komatsu et al., J Pharmacol Toxicol Methods 1999 : These results suggest that the probucol induced increase of [ pH]i was mainly dependent on Na+/H+ exchange and partly on extracellular Ca2+ ... This enhancement of PGI2 generation resulted from increased release of Ca2+ from the storage sites, due not only to increased production of inositol 1,4,5-triphosphate ( IP3 ) but also to the increase of [ pH]i
Unsöld et al., Pflugers Arch 2000 : pHi induced changes in intracellular Ca2+ activity ([Ca2+]i) did not correlate with the current responses
Lustig et al., Biochim Biophys Acta 1992 : Introduction of BAPTA, a calcium buffer, into BPAE cells inhibited ATP mediated increases in [ Ca2+ ] i and PGI2 release, further evidence that PGI2 release is dependent upon an increase in [ Ca2+ ] i
Garcia et al., J Lab Clin Med 1992 : Both the increase in [Ca2+ ] i and PKC activation are required for thrombin stimulated PLA2 and PLD activity, PGI2 synthesis, and barrier dysfunction, the latter occurring as the result of Ca2+ and PKC effects on specific cytoskeletal protein elements and other contractile proteins ( Fig. 3 )
Clesham et al., Cardiovasc Res 1992 : Further, based on the distinct effects of ionomycin and staurosporine, it appears that agonist stimulated PGI2 release from these cells is mediated predominantly by protein kinase C, rather than by rises in intracellular Ca2+
Cingolani et al., Circ Res 2003 : The difference in the SFR magnitude and response to inhibition of reverse mode Na+-Ca2+ exchange can be ascribed to a pHi induced increase in myofilament Ca2+ responsiveness
Ngaiza et al., J Cell Physiol 1992 : A 21-amino acid COOH-terminal peptide of hirudin ( N alpha-acetyldesulfato-hirudin45-65 or Hir45-65 ) inhibited thrombin induced ( 0.5 U/ml ) rises in [Ca2+ ] i and PGI2 production with IC50 of 0.13 and 0.71 microM, respectively
Kawase et al., Zygote 2005 (Calcium Signaling) : Furthermore, the sustained [Ca2+ ] i elevation and acrosome reaction, induced by a combination of ARIS and asterosap, were drastically inhibited by a slight reduction in pHi
Törnquist et al., Endocrinology 1991 : We conclude that in GH4C1 cells, a transient increase in [Ca2+ ] i can enhance Na+/H+ exchange and cause a rise in pHi , but that to obtain full activation of exchange, protein kinase C activity must also be stimulated
Baysal et al., Arch Biochem Biophys 1991 : It is concluded that the Na+/Ca2+ antiport of heart mitochondria is very sensitive to matrix [ H+ ] and that changes in pHi may contribute to the regulation of matrix Ca2+ levels
Bassnett et al., J Physiol 1990 : 3. Acetazolamide, an inhibitor of carbonic anhydrase , had no effect on resting pHi
Schackmann et al., J Biol Chem 1986 : Increasing pHi by adding 10 mM NH4+ or by addition of Li+ to sperm in NaFASW does not increase [ Ca2+ ] i
Hampel et al., Biochim Biophys Acta 1989 : Histamine induced inositol trisphosphate and [Ca2+ ] i responses and the conversion of PGG2 and PGH2 to PGI2 were not altered by selenium deficiency
Muallem et al., Am J Physiol 1989 : However, changes in pHi at constant pHo had no effect on hormone evoked [ Ca2+ ] i increase, reduction in [ Ca2+ ] i after hormone stimulation, or reloading of intracellular stores
Borin et al., Biull Eksp Biol Med 1988 : Removal of Ca2+ from the external solution suppressed pHi increase and correspondingly it enhanced initial decrease
Rosoff et al., J Biol Chem 1985 (Leukemia, Lymphoid) : The associated rise in pHi was dependent on the presence of external Ca2+ and Na+, was inhibited by dimethylamiloride and La3+, and was maintained for at least 20 min. Phorbol esters, which are co-mitogenic in T cells and activate protein kinase C, also stimulated the exchanger, but by a mechanism not requiring an elevation in cytoplasmic Ca2+ ; the rise in pHi rapidly peaked and returned to baseline levels within 20 min. Pretreatment with phorbols prevented an increase in pHi by OKT3 although a transient additive effect was observed when the two were added simultaneously
Siripont et al., Cell Immunol 1988 : Binding of SAP to M phi required Ca2+ or Mg2+ and was inhibited at a pH less than or equal to 5.6
Gelfand et al., J Immunol 1988 : The decrease in pHi was dependent on a sustained increase in cytosolic free Ca2+ and could be mimicked by addition of the divalent cation ionophore, ionomycin
Ritter et al., Br J Pharmacol 1987 : Stimulation by Ca2+ of PGI2 synthesis was concentration dependent over the range 0.7-20 mM ... Nifedipine, but not verapamil or diltiazem, inhibited Ca2+ stimulated PGI2 synthesis ... 8- ( N, N-diethylamino ) -octyl-3,4,5 timethoxybenzoate ( TMB-8 ), an antagonist of intracellular Ca2+ mobilisation, inhibited basal and Ca2+ stimulated PGI2 synthesis to a similar extent ... A solution containing 40 mM K+ reduced Ca2+ stimulated PGI2 production ... Other divalent cations ( Mn2+, Ba2+ and Sr2+ ), and La3+ had little or no effect on basal or Ca2+ stimulated PGI2 synthesis
Kambayashi et al., Thromb Res 1986 : The effect of PGI2 or the analogue on the resting level of intraplatelet Ca2+ concentration ([Ca2+]i) was investigated, utilizing fluorescent Ca2+ indicator quin 2
Wegrowski et al., Biochem J 1986 : PGI and PGII formed insoluble complexes with human LDL in the presence of Ca2+
Erne et al., J Hypertens Suppl 1984 (Hypertension) : PGI2 prevented the thrombin induced increase in [Ca2+ ] i and adrenaline antagonized the effect of PGI2
Duncan et al., Naunyn Schmiedebergs Arch Pharmacol 1980 : 1. The possibility that rapid Ca2+-uptake by skeletal muscle mitochondria may cause local reductions in pHi ( by H+/Ca2+ exchange ) and so promote lysosomal breakdown has been explored using amphibian and mammalian preparations
Sato et al., Neurosci Lett 1994 : A slightly lowered pHo of 7.0 slowly induced a small increase in [Ca2+ ] i and an exponential-like decrease in pHi
Nagesetty et al., Circ Res 1994 : Effects of pHi on isometric force and [Ca2+ ] i in porcine coronary artery smooth muscle
Poch et al., Biochem J 1993 : [ Ca2+ ] i and pHi increases induced by ionomycin were both dependent on the concentration of ionomycin
van de Water et al., Biochem Pharmacol 1993 : Prior to cell death, DCVC induced a rise in [Ca2+ ] i and a decrease in the delta phi
Wheeler-Jones et al., Biochem J 1996 : Ca2+ ionophore induced PGI2 generation, but not vWF secretion, was also inhibited by both genistein and ST271, suggesting that these agents modulate PGI2 synthesis by acting at, or distal to, agonist induced changes in intracellular CA2+ ( [ Ca2+ ] i )
Tamagaki et al., Atherosclerosis 1996 (Arteriosclerosis) : The addition of HDL also enhanced the generation of prostacyclin in endothelial cells, the enhancement of PGI2 generation resulted from an increase in the release of Ca2+ from storage sites, due not only to an increased production of inositol 1,4,5-trisphosphate ( IP3 ), but also to the alkalinization of [ pH]i
Deitmer et al., Glia 1997 : Removal of external Ca2+ reduced the glutamate- and aspartate induced pHi responses to 93 and 72 %, respectively
Smith et al., J Physiol 1998 : 5. The effects of noradrenaline on steady-state pHi and on pHi recovery rates following acid loads were not dependent on changes in [Ca2+ ] i