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CCND1 — SFN

Text-mined interactions from Literome

Wang et al., Int J Oncol 2004 (Prostatic Neoplasms) : SFN induced signals that inhibited the activity of cyclin dependent kinase cdk4 with an up-stream induction of cdk inhibitor p21WAF-1/Cip-1, and reduced cyclin D1
Shen et al., Cancer Chemother Pharmacol 2006 : At high doses ( > 25 microM ), SFN dramatically induces the expression of p21 ( CIP1 ) while significantly inhibits the expression of the G ( 1 ) phase cell cycle regulatory genes such as cyclin D1 , cyclin A, and c-myc ... Furthermore, the activation of the ERK and p38 pathways by SFN is involved in the upregulation of p21 ( CIP1 ) and cyclin D1 , whereas the activation of the JNK pathway plays a contradictory role and may be partially involved in the downregulation of cyclin D1
Roy et al., Journal of molecular signaling 2010 : SFN induced the expression of p21/CIP1 and p27/KIP1, and inhibited the expression of cyclin D1