◀ Back to ABL1
ABL1 — RAD51
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
RAD51
→
ABL1
(directlyIncreases, RAD51 Activity)
Evidence: 11684015;10212258
-
WikiPathways miRNA Regulation of DNA Damage Response:
ABL1
→
RAD51
(activation)
Sengupta et al., Nat Rev Mol Cell Biol 2005*, Harrison et al., Annu Rev Genet 2006*, Toledo et al., Nat Rev Cancer 2006*, Vousden et al., Nat Rev Mol Cell Biol 2007*, Boutros et al., Nat Rev Cancer 2007*, Wang et al., Nat Rev Genet 2007*, Löbrich et al., Nat Rev Cancer 2007*, Antoni et al., Nat Rev Cancer 2007*
-
WikiPathways ATM Signaling Pathway:
ABL1
→
RAD51
(mim-stimulation)
-
WikiPathways DNA Damage Response:
ABL1
→
RAD51
(activation)
Sengupta et al., Nat Rev Mol Cell Biol 2005*, Harrison et al., Annu Rev Genet 2006*, Toledo et al., Nat Rev Cancer 2006*, Vousden et al., Nat Rev Mol Cell Biol 2007*, Boutros et al., Nat Rev Cancer 2007*, Wang et al., Nat Rev Genet 2007*, Löbrich et al., Nat Rev Cancer 2007*, Antoni et al., Nat Rev Cancer 2007*
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
RAD51
—
ABL1
(physical association, affinity chromatography technology)
Chen et al., J Biol Chem 1999*
-
IRef Biogrid Interaction:
RAD51
—
ABL1
(direct interaction, pull down)
Chen et al., J Biol Chem 1999*
-
IRef Hprd Interaction:
RAD51
—
ABL1
(in vitro)
Chen et al., J Biol Chem 1999*, Yuan et al., J Biol Chem 1998*
-
IRef Hprd Interaction:
RAD51
—
ABL1
(in vivo)
Chen et al., J Biol Chem 1999*, Yuan et al., J Biol Chem 1998*
-
IRef Intact Interaction:
RAD51
—
ABL1
(physical association, pull down)
Popova et al., FEBS Lett 2009*
Text-mined interactions from Literome
Chen et al., J Biol Chem 1999
:
Our data suggest signaling mediated through ATM, and
c-Abl is
required for the correct post-translational modification of
Rad51 , which is critical for the assembly of Rad51 repair protein complex following I-R
Slupianek et al., Mol Cell 2001
:
BCR/ABL significantly
enhances the expression of RAD51 and several
RAD51-Paralogs
Yuan et al., Mutat Res 2003
(Chromosome Breakage) :
In conclusion, effective and prompt IR-induced
Rad51 focus formation is cell cycle regulated and
requires both ATM and
c-Abl
Slupianek et al., Blood 2011
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
In conclusion, we postulate that
BCR-ABL1 kinase
mediated RAD51 ( pY315 ) promotes unfaithful HomeoRR in leukemia cells, which may contribute to accumulation of secondary chromosomal aberrations responsible for CML relapse and progression
Yuan et al., J Biol Chem 1998
:
The results also show that treatment of cells with ionizing radiation induces
c-Abl dependent phosphorylation of
Rad51