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EGR1 — RAF1

Text-mined interactions from Literome

Guillemot et al., J Biol Chem 2001 (MAP Kinase Signaling System) : Moreover, using a co-transfection approach, we found that Ang II induction of Egr-1 promoter activity was blocked by dominant negative p21(ras), Raf-1 , and tyrosine phosphatase SHP-2 mutants ... Taken together, these findings demonstrate that Ang II-induced cyclin D1 up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region, both in a p21(ras)/Raf-1/MEK/ERK dependent manner, and also involves PI3K and SHP-2
Qureshi et al., J Biol Chem 1991 : The involvement of c-Raf-1 in v-Src induced Egr-1 expression was investigated using an inhibitory mutant of c-Raf-1
Lin et al., PloS one 2013 (Hyperglycemia...) : EGR-1 siRNA also reduced GDNF/EGR-1 induced cRaf/MEK/ERK phosphorylation by 80 %