◀ Back to RAF1
PAK6 — RAF1
Pathways - manually collected, often from reviews:
-
KEGG Focal adhesion:
PAK1/PAK2/PAK3/PAK4/PAK6/PAK7
→
RAF1
(protein-protein, phosphorylation)
-
WikiPathways Focal Adhesion:
PAK1/PAK3/PAK2/PAK4/PAK7/PAK6
→
ARAF/BRAF/RAF1
(activation)
Text-mined interactions from Literome
Sun et al., Curr Biol 2000
:
Thus, Raf-1 activation by Ras is achieved through a combination of both physical interaction and indirect mechanisms involving the activation of a second Ras effector, PI 3-kinase, which directs
Pak mediated regulatory phosphorylation of
Raf-1
King et al., FEBS Lett 2001
:
Phosphorylation site specificity of the
Pak mediated regulation of
Raf-1 and cooperativity with Src
Beeser et al., J Biol Chem 2005
:
Inhibition of
Pak reduced the Ser ( 338 ) phosphorylation of
c-Raf in response to both PDGF and EGF ; however, in the case of EGF, the reduction in Ser ( 338 ) phosphorylation was not accompanied by a significant decrease in c-Raf activity
Wu et al., J Cell Biochem 2008
:
We observed that all group II PAKs were efficient serine 338 kinases, although only PAK1 and
PAK5 significantly
stimulated Raf-1 kinase activity