Saegusa et al., Int J Cancer 2006
(Disease Progression...) :
Induction of p16INK4A mediated by beta-catenin in a TCF4 independent manner : implications for alterations in p16INK4A and pRb expression during trans-differentiation of endometrial carcinoma cells ... These findings indicate that induction of p16(INK4A) mediated by nuclear beta-catenin and p21 ( WAF1 ), along with loss of pRb expression, may be important for initial steps during trans-differentiation of Em Ca cells
Wassermann et al., Gastroenterology 2009
(Colorectal Neoplasms...) :
In colorectal carcinomas, expression of the p16(INK4A) gene is regulated by beta-catenin/TCF4 and correlates with low survival rates of patients with tumors displaying an infiltrative front of invasion