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BMP2 — COMP

Text-mined interactions from Literome

Kipnes et al., Osteoarthritis Cartilage 2003 : However, at later times in micromass culture, ectopic COMP expression in the presence of BMP-2 causes an increase in apoptosis, with an accompanying reduction in cell numbers in the micromass culture
Tian et al., Beijing Da Xue Xue Bao 2003 : [ Effects of bone morphogenetic protein-2 on cartilage oligomeric matrix protein expression in chondrocytes ] ... To quantitatively evaluate the effects of BMP-2 on the COMP gene expression in both primary human chondrocytes and chondrogenic cell line ATDC55 ... We found that BMP-2 up-regulated COMP gene expression by approximate 3 folds in human adult chondrocytes, and 1.5 folds in human fetal chondrocytes ... For further analysis of the effect of BMP-2 on COMP gene expression by RT-PCR, a rat chondrogenic cell line of ATDC55 cells was used
Ishida et al., Bone 2013 (Choristoma...) : COMP binding enhanced BMP-2 induced intracellular signaling through Smad proteins, increased the levels of BMP receptors, and up-regulated the luciferase activity from a BMP-2-responsive reporter construct ... In summary, this study demonstrates that COMP enhances the osteogenic activity of BMP-2 , both in-vitro and in-vivo