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CSF2 — PTGS2

Text-mined interactions from Literome

Stanford et al., Br J Pharmacol 2000 : Here we demonstrate, for the first time, that co-induced COX-2 activity simultaneously suppresses GM-CSF release and potentiates G-CSF release by human vascular cells ... Moreover, the differential regulation of GM-CSF and G-CSF release by COX-2 was mimicked by the prostacyclin ( PGI ( 2 ) ) mimetic, cicaprost
Stanford et al., Arterioscler Thromb Vasc Biol 2000 (Arteriosclerosis) : Cyclooxygenase-2 regulates granulocyte-macrophage colony stimulating factor , but not interleukin-8, production by human vascular cells : role of cAMP ... Under the same conditions, we found that COX-2 activity suppressed GM-CSF , but not IL-8, release by both types of human vascular cells
Calatayud et al., Br J Pharmacol 2001 (Colonic Neoplasms) : 4. No changes in any CSF release or HT-29 cell apoptosis were detected in the presence of the COX-2 selective inhibitor DFP ( 10 ( -7 ) -10 ( -4 ) M )
Nakata et al., Cancer Sci 2003 (Disease Progression...) : It is known that increased COX-2 activity promotes tumor growth and induces G-CSF and GM-CSF expression in non-malignant cells, and that selective COX-2 inhibitors inhibit the growth of some types of malignant cells ... Therefore, we hypothesized that inhibition of COX-2 activity might suppress constitutive production of G-CSF or GM-CSF in addition to reducing the growth of malignant cells ... We confirmed that the selective COX-2 inhibitor, NS-398 suppressed the constitutive production of G-CSF and GM-CSF , and the cell growth in both OKa-C-1 and MI-4 cell lines
Jiang et al., Mol Cell Biochem 2003 : In this study, the effect of phorbol 12-myristate 13-acetate ( PMA ), tumor necrosis factor alpha (TNFalpha), lipopolysaccharide (LPS) and macrophage-colony stimulating factor ( M-CSF ) on AA release and prostaglandin E2 ( PGE2 ) production and the expression of cPLA2 and COX-1 and -2 were investigated in U937 human pre-monocytic cells and fully differentiated macrophages
Wang et al., Fertil Steril 2006 : After treatment of 12 hours, low-dose GM-CSF ( 0.001-0.1 ng/mL ) increased COX-2 mRNA levels in stromal cell, whereas high dose GM-CSF ( 1-100 ng/mL ) decreased COX-1 and COX-2 mRNA levels ... There appeared to be a biphasic pattern of COX-2 enzyme response to GM-CSF with low concentrations increasing activity and high concentrations inhibiting activity
Shoji et al., Acta Biochim Biophys Sin (Shanghai) 2007 : By itself, nicotine did not affect expression of COX-1, COX-2, any of the PGE ( 2 ) receptors, or M-CSF , but when both nicotine and LPS were present, expression of COX-2 , Ep3, Ep4, and M-CSF increased significantly
Sanuki et al., Connect Tissue Res 2010 : Celecoxib, a specific inhibitor of COX-2 , blocked the stimulatory effect of CF on TRAP staining and the production of PGE ( 2 ), M-CSF , RANKL, and OPG