◀ Back to ABL1

ABL1 — GRB2

Pathways - manually collected, often from reviews:

• KEGG Pathways in cancer: ABL1/BCR → GRB2 (protein-protein, activation)
• KEGG Chronic myeloid leukemia: ABL1/BCR → GRB2 (protein-protein, activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: GRB2 — ABL1 (direct interaction, pull down) Ren et al., Genes Dev 1994*
• IRef Biogrid Interaction: GRB2 — ABL1 (physical association, affinity chromatography technology) Patel et al., Genes Chromosomes Cancer 2006*
• IRef Biogrid Interaction: GRB2 — ABL1 (physical association, affinity chromatography technology) Johnson et al., PloS one 2009*
• IRef Biogrid Interaction: GRB2 — ABL1 (direct interaction, pull down) Gaston et al., Exp Hematol 2004*
• IRef Biogrid Interaction: GRB2 — ABL1 (direct interaction, two hybrid) Gaston et al., Exp Hematol 2004*
• IRef Biogrid Interaction: GRB2 — ABL1 (physical association, affinity chromatography technology) Chen et al., Blood 2013*
• IRef Biogrid Interaction: GRB2 — ABL1 (physical association, affinity chromatography technology) Brehme et al., Proc Natl Acad Sci U S A 2009
• IRef Biogrid Interaction: GRB2 — ABL1 (physical association, affinity chromatography technology) Warmuth et al., J Biol Chem 1997*
• IRef Biogrid Interaction: GRB2 — ABL1 (direct interaction, two hybrid) Ren et al., Genes Dev 1994*
• IRef Hprd Interaction: Complex of ABL1-GRB2-CBL-GRB2-CBL-CBL-ABL1-GRB2-ABL1 (in vivo) Gaston et al., Exp Hematol 2004*
• IRef Hprd Interaction: ABL1 — GRB2 (two hybrid) Gaston et al., Exp Hematol 2004*, Ren et al., Genes Dev 1994*, Romero et al., J Biol Chem 1998*
• IRef Hprd Interaction: ABL1 — GRB2 (in vitro) Gaston et al., Exp Hematol 2004*, Ren et al., Genes Dev 1994*, Romero et al., J Biol Chem 1998*
• IRef Innatedb Interaction: GRB2 — ABL1 (unknown, -) Feng et al., J Biol Chem 1996
• IRef Intact Interaction: GRB2 — ABL1 (physical association, peptide array) Wu et al., Proteomics 2007
• IRef Ophid Interaction: GRB2 — ABL1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Jahn et al., J Biol Chem 2001 : We demonstrate that the inhibitory activity of Grb4 is independent of the direct interaction of v-Abl and Grb4 : a Grb4 mutant that lacks a functional SH2 domain shows an even more pronounced inhibition of AP-1/SRE
Gaston et al., Exp Hematol 2004 : In a yeast three-hybrid assay, Grb2 mediated an interaction between Cbl and Bcr-Abl that was dependent on a functional Grb2 binding site ... Grb2 or another, yet unidentified, protein may mediate an initial interaction between Cbl and Bcr-Abl that is independent of Cbl tyrosine phosphorylation
Modi et al., Leukemia 2011 (Cell Transformation, Neoplastic...) : The adapter protein growth factor receptor binding protein-2 ( Grb2 ) can bind phosphorylated BCR/ABL-Y177 , induce Grb2-SoS complex formation and activate Ras signaling
Tanaka et al., Mol Cell Biol 1995 : Activation of Erk-1 by oncogenic Abl was effectively inhibited by Grb2 with mutations in either its SH2 or SH3 domain or by Crk-1 with an SH3 domain mutation ... These results suggest that both Crk and Grb2 may contribute to the activation of Erk by oncogenic Abl , whereas Nck is unlikely to participate in this pathway