◀ Back to ABL1
ABL1 — RAC1
Pathways - manually collected, often from reviews:
-
KEGG Viral myocarditis:
ABL1/ABL2
→
RAC1/RAC2/RAC3
(protein-protein, activation)
-
NCI Pathway Database PDGFR-beta signaling pathway:
RAC1/GDP complex (RAC1)
→
c-Abl (ABL1)
(modification, collaborate)
Furstoss et al., EMBO J 2002, Boureux et al., J Cell Sci 2005
Evidence: mutant phenotype
-
NCI Pathway Database PDGFR-beta signaling pathway:
c-Abl (ABL1)
→
RAC1/GTP complex (RAC1)
(modification, activates)
Furstoss et al., EMBO J 2002, Boureux et al., J Cell Sci 2005
Evidence: mutant phenotype
-
NCI Pathway Database PDGFR-beta signaling pathway:
RAC1/GTP complex (RAC1)
→
c-Abl (ABL1)
(modification, activates)
Innocenti et al., J Cell Biol 2002, Eden et al., Nature 2002, Steffen et al., EMBO J 2004*, Sini et al., Nat Cell Biol 2004, Innocenti et al., Nat Cell Biol 2004, Leng et al., Proc Natl Acad Sci U S A 2005
Evidence: assay, physical interaction
-
Reactome Reaction:
ABL1
→
RAC1
(reaction)
Leng et al., Proc Natl Acad Sci U S A 2005
Text-mined interactions from Literome
Bassermann et al., J Biol Chem 2002
:
The oncogenic tyrosine kinase
Bcr-Abl has been shown to
activate Rac-1 , which is important for Bcr-Abl induced leukemogenesis ...
Activation of
Rac-1 by
Bcr-Abl was abrogated by co-expression of the Vav C terminus encoding the SH3-SH2-SH3 domains as a dominant negative construct
Sini et al., Nat Cell Biol 2004
:
Genetic or pharmacological interference with
Abl ( and the related kinase Arg )
resulted in a marked decrease in
Rac activation induced by physiological doses of growth factors
Sirvent et al., Oncogene 2007
(Breast Neoplasms...) :
In contrast,
Abl controls the activation of the small GTPase
Rac for oncogenic signalling and active Rac partly rescued Src transformation in cells with inactive Abl
Jin et al., Mol Biol Cell 2007
:
The
Abl dependent dorsal membrane localization of activated
Rac explains its positive role in ruffling and negative role in cell spreading and migration
Skorski et al., Proc Natl Acad Sci U S A 1998
(Leukemia, Experimental...) :
We show here that the small GTP binding protein
Rac is
activated by
BCR/ABL in a tyrosine kinase dependent manner