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AOM — CDKN1A

Text-mined interactions from Literome

Roy et al., Int J Oncol 2011 (Colonic Neoplasms) : Immunohistochemical analysis revealed that while AOM decreased the p21 expression ( 75 %, p < 0.01 ) in the premalignant colonic mucosa, PEG induced p21 levels back to normal
Singh et al., Int J Oncol 1995 : AOM-treatment resulted in increasingly higher levels of membrane bound ras-p21 with advancing stages of colon tumorigenesis without any significant changes in cytoplasmic ras-p21 ... Dietary DFMO significantly suppressed AOM induced membrane bound ras-p21 in a time dependent manner
Singh et al., Int J Oncol 1994 : Sulindac not only suppressed the selective amplification of initiated cells possessing AOM induced mutated K-ras codon 12, but significantly inhibited the AOM induced expression of total and mutant ras-p21
Singh et al., Carcinogenesis 1994 (Colonic Neoplasms) : In our previous study, we demonstrated that azoxymethane (AOM) treatment significantly enhanced the expression of ras p21, the protein product of ras genes, and that the dietary administration of chemopreventive agents such as D, L-alpha-difluoromethylornithine ( DFMO ), a irreversible inhibitor of ornithine decarboxylase, and piroxicam, a non-steroidal anti-inflammatory drug ( NSAID ), exerted a significant inhibitory effect on AOM induced ras p21 expression