UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to MAPK8

MAPK8 — TRAF2

Pathways - manually collected, often from reviews:

KEGG Adipocytokine signaling pathway: TRAF2 → MAPK10/MAPK8/MAPK9 (protein-protein, activation)
NCI Pathway Database CD40/CD40L signaling: JNK family (MAPK8/MAPK9/MAPK10) → CD40/CD40L (trimer)/TRAF2 (trimer) complex (CD40LG-CD40-TRAF2) (modification, collaborate)
Pullen et al., J Biol Chem 1999, Davies et al., Mol Cell Biol 2005, Rowland et al., J Immunol 2007
Evidence: mutant phenotype, assay

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Biogrid Interaction: TRAF2 — MAPK8 (physical association, affinity chromatography technology) Gravestein et al., Eur J Immunol 1998 *
IRef Hprd Interaction: Complex of RIPK1-TRAF2-TRAF2-MAPK8-RIPK1-RIPK1-TRAF2-MAPK8-MAPK8 (in vivo) Shen et al., Mol Cell Biol 2004 *

Text-mined interactions from Literome

Horie et al., Microbes Infect 2007 (HIV Infections) : TRAF activation of C/EBPbeta ( NF-IL6 ) via p38 MAPK induces HIV-1 gene expression in monocytes/macrophages
Funakoshi-Tago et al., Cytokine 2009 : On the other hand, TRAF6 deficiency did not affect the TNFalpha induced activation of mitogen activated protein ( MAP ) kinases , ERK, JNK, and p38
Mikkelsen et al., J Biol Chem 2009 : We also observed that TRAF2 and TAK1 were essential for RIG-I mediated activation of p38 MAPK