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IFNG — TLR4

Text-mined interactions from Literome

Faure et al., J Immunol 2001 (Inflammation...) : Bacterial lipopolysaccharide and IFN-gamma induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells : role of NF-kappa B activation
Mita et al., Immunol Lett 2001 : IFN-gamma up-regulated both TLR2 and TLR4 , but enhanced the surface expression, on human peripheral blood monocytes of TLR4 more than that of TLR2
Tamai et al., Infect Immun 2002 : To elucidate the mechanism of the priming effects of IFN-gamma for the LPS response by HGF, we examined whether IFN-gamma regulated expression of CD14, Toll-like receptor 2 (TLR2), TLR4 , MD-2, and MyD88, all of which are molecules suggested to be associated with LPS signaling
Abreu et al., J Biol Chem 2002 : IFN-gamma regulates MD-2 expression in both IEC lines, whereas IFN-gamma and TNF-alpha regulate TLR4 mRNA expression in IEC lines
Bosisio et al., Blood 2002 : Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-gamma : a molecular basis for priming and synergism with bacterial lipopolysaccharide
Okamoto et al., J Natl Cancer Inst 2003 (Head and Neck Neoplasms) : Involvement of Toll-like receptor 4 signaling in interferon-gamma production and antitumor effect by streptococcal agent OK-432
Pivarcsi et al., Int Immunol 2003 : LPS + IFN-gamma increased the expression of TLR2 and TLR4 50- and 5-fold respectively
Tamai et al., J Endotoxin Res 2003 : LPS and IFN-gamma enhanced mCD14 and Toll-like receptor (TLR) 4 expression in THP-1 cells, respectively, and co-stimulation with LPS and IFN-gamma induced higher levels of mCD14 and TLR4 expression than stimulation with either agent alone
Heldwein et al., J Leukoc Biol 2003 (Tuberculosis) : A role for TLR4 in the control of bacterial growth and IFN-gamma production in vivo was observed only when mice were infected with higher numbers of BCG
Rothfuchs et al., J Immunol 2004 : Intracellular bacterial infection induced IFN-gamma is critically but not solely dependent on Toll-like receptor 4-myeloid differentiation factor 88-IFN-alpha beta-STAT1 signaling
Mochizuki et al., J Periodontal Res 2004 : Expression of MyD88 but not TLR4 was also enhanced by IFN-gamma
Pai et al., Infect Immun 2004 : Microarray gene expression studies were then used to determine whether prolonged TLR signaling by M. tuberculosis broadly inhibits IFN-gamma regulation of macrophage gene expression
Yamada et al., J Urol 2005 (Urinary Bladder Neoplasms) : IFN-gamma up-regulated the expression of TLR-4 , which is an LPS binding receptor
van der Graaf et al., Infect Immun 2005 (Candidiasis) : After stimulation with blastoconidia, the production of IFN-gamma was TLR4 dependent , as shown by the significantly decreased IFN-gamma production in anti-TLR4 treated PBMC and in splenic lymphocytes from TLR4-defective ScCr mice
Motegi et al., J Leukoc Biol 2006 (Shock, Septic...) : IL-12 induced IFN-gamma up-regulated Toll-like receptor 4 (TLR-4) on macrophages of adults
Banus et al., Infect Immun 2006 (Genetic Predisposition to Disease...) : Functional Tlr4 is essential for an efficient IL-1-beta, TNF-alpha, and IFN-gamma response ; efficient clearance of bacteria from the lung ; and reduced lung pathology
Mueller et al., J Immunol 2006 : The down-regulatory effect of Th2 cytokines on TLR expression and function in IECs also counteracted enhanced TLR signaling induced by stimulation with the hallmark Th1 cytokine IFN-gamma
Eriksson et al., J Immunol 2006 : However, purified uNK cells did not respond directly to TLR agonists, but IFN-gamma was produced by uNK cells in response to TLR stimulation when cocultured with APCs
Velayudham et al., J Hepatol 2006 (Granuloma...) : IFNgamma induction by P. acnes, TLR2 and TLR9 ligands required MyD88
Ramakers et al., Cytokine 2006 : Cl-IB-MECA inhibited TLR4-agonist induced IFN-gamma release ... In more detail, CPA potentiated TLR5 mediated IL-6 production, TLR3 mediated IFN-gamma production and TLR3 mediated Il-1beta production compared to TLR4 mediated stimulation
Pearl-Yafe et al., Shock 2007 : In human neutrophils, interferon (IFN)-gamma enhanced the expression of toll-like receptor 4 (TLR4) , a crucial component of the signaling receptor complex for bacterial lipopolysaccharide (LPS) ... Using the protein synthesis inhibitor cycloheximide and measuring the expression of CD35 in neutrophils stimulated with IFN-gamma and LPS alone or in combination, we could demonstrate that IFN-gamma enhances TLR4 by de novo protein synthesis, whereas the addition of LPS acts synergistically by enhancing vesicular mobilization to the cell surface
Copin et al., J Immunol 2007 (Brucellosis) : Using genetically deficient mice, we demonstrated that the induction of iNOS and IFN-gamma producing cells due to Brucella infection required TLR4 and TLR9 stimulation coupled to Myd88 dependent signaling pathways
Isono et al., Dig Dis Sci 2007 : Treatment with C. butyricum TO-A culture supernatant significantly reduced TLR4 mRNA level ( x0.16 ), even in the presence of interferon-gamma ( IFN-gamma ; x0.21 ) as compared with untreated controls
Hu et al., J Leukoc Biol 2007 : IFN-gamma suppresses TLR2 and TLR4 induction/activation of AP-1 by overlapping mechanisms that include regulation of MAPKs, GSK3 dependent suppression of DNA binding, and decreased Fos and Jun protein expression and stability
Girart et al., J Immunol 2007 (Melanoma) : Engagement of TLR3, TLR7 , and NKG2D regulate IFN-gamma secretion but not NKG2D mediated cytotoxicity by human NK cells stimulated with suboptimal doses of IL-12
Kobayashi et al., Clin Immunol 2007 (Colitis, Ulcerative...) : We previously reported that human mast cells (MCs) express high affinity IgG receptor ( FcgammaRI ) and Toll-like receptor 4 (TLR4) in response to interferon (IFN)-gamma in vitro
Barr et al., Eur J Immunol 2007 : In this study, we investigated which mouse B cell subsets are the most potent cytokine producers, and examined the role of Toll-like receptors ( TLR ) in the control of secretion of IL-6, IL-10, IL-12 and IFN-gamma by B cells ... Thus, in response to combined TLR stimulation, or via phorbol esters, IFN-gamma was secreted
Allam et al., J Allergy Clin Immunol 2008 : Moreover, TLR4-ligation on oLCs induced IL-10, TGF-beta1, Forkhead box protein 3, IFN-gamma , and IL-2 production in T cells
O'Mahony et al., International journal of medical sciences 2008 : Of the cytokines examined, IFN-gamma and GM-CSF caused the greatest effects on TLR expression ... IFN- gamma up-regulated TLR2 and TLR4 in neutrophils and monocytes
Furuta et al., Eur J Immunol 2008 (Malaria) : Innate immune responses to PbAPrx were examined using cells from mice deficient in Toll-like receptors ( TLR ) or related molecules, and it was demonstrated that responses were severely impaired in TLR4 ( -/- ), MyD88 ( -/- ) and MD-2 ( -/- ) mice, but not in Toll/IL-1 receptor domain containing adaptor inducing IFN-gamma ( TRIF ) ( -/- ), TLR2 ( -/- ) or radioprotective 105 ( RP105 ) ( -/- ) mice
Prescott et al., J Allergy Clin Immunol 2008 (Hypersensitivity...) : Maternal allergy ( n = 59 ) was associated with significantly higher neonatal IL-12 and IFN-gamma responses to TLR2, TLR3 , and TLR4 activation, whereas TNF-alpha and IL-6 responses to TLR2, TLR4, and TLR5 activation were significantly higher in newborns who subsequently had allergic disease ( n = 32 ) ... Maternal allergy ( n = 59 ) was associated with significantly higher neonatal IL-12 and IFN-gamma responses to TLR2, TLR3, and TLR4 activation, whereas TNF-alpha and IL-6 responses to TLR2, TLR4, and TLR5 activation were significantly higher in newborns who subsequently had allergic disease ( n = 32 )
Spiller et al., J Exp Med 2008 (Escherichia coli Infections...) : TLR4 induced IFN-gamma production increases TLR2 sensitivity and drives Gram negative sepsis in mice ... Both murine splenocytes and human PBMCs released IFN-gamma in a TLR4 dependent manner, leading to enhanced surface TLR2 expression and sensitivity for TLR2 ligands
Farkas et al., Scand J Immunol 2008 : Our study provides evidence that NOD2, toll-like receptor 4 (TLR4) and the adapter protein receptor interacting protein 2 (RIP2) are induced by tumor-necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) in the bronchial epithelial cell line BEAS-2B
Archer et al., Cell Microbiol 2009 : Thus, MyD88 dependent innate immune responses induced by L. pneumophila involve both TLR dependent responses and IL-18R dependent production of IFN-gamma by natural killer cells, and these MyD88 dependent pathways can function independently to provide host protection against an intracellular pathogen
Yarovinsky et al., J Immunol 2008 (Acute Disease...) : We further show that this immunopathology is the result of non-TLR dependent activation of IFN-gamma secretion by NK cells in response to the infection
Bou Ghanem et al., Infect Immun 2009 (Listeriosis) : Although it has been suggested that CDC protein toxins may act as Toll-like receptor 4 (TLR4) agonists to trigger proinflammatory cytokine secretion, we show in this report that TLR4 signaling is not required to induce a maximal rapid IFN-gamma response by CD8+ T cells
Wu et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2009 : IgG stimulation induced a significant TLR4 expression and TNF-alpha secretion in cultured microglial cells in a dose dependent manner, while IFN-gamma was not detected in the same medium samples
Lotter et al., PLoS Pathog 2009 (Disease Models, Animal...) : IFN-gamma production by NKT cells requires the presence of CD1d and simultaneously TLR receptor signalling through MyD88 and secretion of IL-12
Covacu et al., J Immunol 2009 : TLR4 was up-regulated by IFN-gamma and this effect was reversed by TNF-alpha
Chassin et al., J Immunol 2009 (Genetic Predisposition to Disease...) : We also found a protective tissue compartmentalized TLR2/TLR4 mediated production of IFN-gamma by B and T lymphocytes, in the liver and kidney, respectively
Devilder et al., J Immunol 2009 : Moreover TLR induced Vgamma9Vdelta2 IFN-gamma noncytolytic response led to efficient DC polarization into IL-12p70 producing cells
Lee et al., J Parasitol 2010 : We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether TLR and MUC expression is regulated by interferon (IFN)-gamma , interleukin-4, or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen
Cui et al., Biology direct 2009 : Third, the expressions of both Toll-like receptor (TLR)2 and TLR4 on surface of LA-activated gammadelta T cells were upregulated, whereas only anti-TLR4 antibody could partially block their response to LA ; Finally LA-loaded moDCs induce gammadelta T cells to produce Th1 cytokines, such as IFN-gamma
van Hoffen et al., Int Arch Allergy Immunol 2010 : Apically added LGG, TLR2 and NOD2 ligands, but not Bb, enhanced IFN-gamma , IL-12 and/or TNF-alpha secretion
Fang et al., FEMS Immunol Med Microbiol 2010 (West Nile Fever) : Viral antigens were detected in WNV infected gammadelta T cells.WNV infection or toll-like receptor ( TLR ) agonist treatment of gammadelta T cells induced the production of IFN-gamma , tumor necrosis factor-alpha and IL-6, which are known to promote DC maturation
Oliveira et al., PLoS Pathog 2010 (Chagas Disease) : Our studies demonstrated that TLR4 signaling is required for optimal production of IFN-gamma , TNF-alpha and nitric oxide ( NO ) in the spleen of infected animals and, as a consequence, Tlr4 ( -/- ) mice display higher parasitemia levels
Brisbin et al., Benef Microbes 2012 : The results demonstrated that chicken CD4+ and CD8+ T-cells express TLR21 and that the various isolates of lactobacilli differentially induces the expression of interleukin 10, interferon-gamma and transforming growth factor beta