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LTA — PTGS2
Text-mined interactions from Literome
Lee et al., Am J Pathol 2010
(Inflammation) :
In this study,
LTA induced cPLA(2) and
COX-2 expression and PGE ( 2 ) or IL-6 synthesis were attenuated by transfection with siRNAs of TLR2, MyD88, Akt, p42, p38, JNK2, and p65 or pretreatment with the inhibitors of PI3K ( LY294002 ), p38 ( SB202190 ), MEK1/2 ( U0126 ), JNK1/2 ( SP600125 ), and NF-kappaB ( helenalin ) in human tracheal smooth muscle cells ( HTSMCs ) ...
LTA also
induced cPLA(2) and
COX-2 expression and leukocyte count in bronchoalveolar lavage fluid in mice
Huang et al., Toxicol Appl Pharmacol 2013
(Inflammation) :
Administration of TLR2 antagonist effectively inhibited
LTA induced NO, iNOS, and
COX-2 expression ... We also found that
LTA induced iNOS and
COX-2 up-regulation were attenuated by p38, JNK, and PI3-kinase inhibitors ... Treatment of cells with NF-?B and AP-1 inhibitors antagonized
LTA induced iNOS and
COX-2 expression