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ENG — SMAD3

Pathways - manually collected, often from reviews:

• WikiPathways Hypothesized Pathways in Pathogenesis of Cardiovascular Disease: ENG → Complex of TGFBR2-TGFBR1-SMAD2-SMAD3 (activation)
  

Text-mined interactions from Literome

Guo et al., Anticancer Res 2004 : CD105 inhibits transforming growth factor-beta-Smad3 signalling ... Furthermore, CD105 overexpression reduced serine phosphorylation of Smad3 and inhibited subsequent nuclear translocation of Smad3 ... c-Jun is known to inhibit Smad3 transcriptional activity on CAGA sites, suggesting that CD105 may also inhibit Smad3 signalling through JNK1
Finnson et al., Osteoarthritis Cartilage 2010 (Osteoarthritis) : Endoglin differentially regulates TGF-ß induced Smad2/3 and Smad1/5 signalling and its expression correlates with extracellular matrix production and cellular differentiation state in human chondrocytes ... Endoglin enhances TGF-ß1 induced Smad1/5 phosphorylation and inhibits TGF-ß1 induced Smad2 phosphorylation, Smad3-driven transcriptional activity and ECM production in human chondrocytes