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HDAC1 — SMAD3
Pathways - manually collected, often from reviews:
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NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
SKI/SIN3/HDAC complex/NCoR1 complex (SKI-NCOR1-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2)
→
SMAD3/SMAD4 complex (SMAD3-SMAD4)
(modification, inhibits)
Luo et al., Genes Dev 1999, Akiyoshi et al., J Biol Chem 1999, Yahata et al., J Biol Chem 2000, Kim et al., Genes Dev 2000, Simonsson et al., J Biol Chem 2006, Tu et al., J Biol Chem 2007, Janknecht et al., Genes Dev 1998, Feng et al., Genes Dev 1998, Shioda et al., Proc Natl Acad Sci U S A 1998, Pouponnot et al., J Biol Chem 1998
Evidence: mutant phenotype, reporter gene, physical interaction
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Reactome Reaction:
HDAC1
→
SMAD3
(reaction)
Wotton et al., Cell 1999, Melhuish et al., J Biol Chem 2001
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Reactome Reaction:
HDAC1
→
SMAD3
(indirect_complex)
Wotton et al., Cell 1999, Melhuish et al., J Biol Chem 2001
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Qiu et al., Biochem Biophys Res Commun 2006
:
In contrast, overexpressing
HDAC 1-6 inhibits TGFbeta1 induced as well as
Smad3 and myocardin activated SM22 promoter
Li et al., Gastroenterology 2007
(Carcinoma, Hepatocellular...) :
This study provides the first evidence that TGFbeta1 represses CYP7A1 gene transcription in human hepatocytes by a mechanism involving
Smad3 dependent inhibition of HNF4alpha and
HDAC remodeling of CYP7A1 chromatin