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PTHLH — SMAD3

Text-mined interactions from Literome

Pateder et al., J Cell Physiol 2001 : Co-transfection of the TGF-beta signaling molecule, Smad 3, mimicked the effect of TGF-beta ( induction of PTHrP promoter ), while dominant negative Smad 3 inhibited the induction of the PTHrP promoter by TGF-beta ... In contrast, a dominant negative Smad 3 completely inhibited PTHrP promoter stimulation by TGF-beta, but only partially blocked the effect of TGF-beta on PTHrP mRNA synthesis
Kakonen et al., J Biol Chem 2002 (Bone Neoplasms...) : Stable transfection of wild-type Smad2, Smad3, or Smad4 increased TGF-beta stimulated PTHrP secretion, whereas dominant negative Smad2, Smad3 , or Smad4 only partially reduced TGF-beta stimulated PTHrP secretion
Lindemann et al., Biochem J 2003 (Breast Neoplasms...) : In invasive MDA-MB-231 breast cancer cells, transforming growth factor beta regulated PTHrP synthesis is mediated by an Ets1/Smad3 dependent activation of the PTHrP P3 promoter
Cao et al., Regul Pept 2013 : We found that ( 1 ) TGF-ß induces PTHrP mRNA expression, protein expression and secretion in a time dependent fashion ; ( 2 ) knockdown of PTHrP gene expression or neutralization of secreted PTHrP isoforms blocks TGF-ß induced apoptosis ; and ( 3 ) TGF-ß induced PTHrP expression is Smad3 dependent