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DAXX — TP53

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TP53 — DAXX (physical association, affinity chromatography technology) Ohiro et al., Mol Cell Biol 2003*
• IRef Biogrid Interaction: TP53 — DAXX (direct interaction, pull down) Ohiro et al., Mol Cell Biol 2003*
• IRef Biogrid Interaction: TP53 — DAXX (direct interaction, two hybrid) Ohiro et al., Mol Cell Biol 2003*
• IRef Biogrid Interaction: TP53 — DAXX (direct interaction, two hybrid) Kim et al., Nucleic Acids Res 2003*
• IRef Biogrid Interaction: TP53 — DAXX (physical association, affinity chromatography technology) Kim et al., Nucleic Acids Res 2003*
• IRef Biogrid Interaction: TP53 — DAXX (direct interaction, two hybrid) Zhao et al., J Biol Chem 2004*
• IRef Biogrid Interaction: TP53 — DAXX (physical association, affinity chromatography technology) Wethkamp et al., J Biol Chem 2011*
• IRef Biogrid Interaction: TP53 — DAXX (physical association, affinity chromatography technology) Zhao et al., J Biol Chem 2004*
• IRef Biogrid Interaction: TP53 — DAXX (physical association, affinity chromatography technology) Gostissa et al., J Biol Chem 2004*
• IRef Biogrid Interaction: TP53 — DAXX (direct interaction, pull down) Gostissa et al., J Biol Chem 2004*
• IRef Biogrid Interaction: TP53 — DAXX (direct interaction, two hybrid) Gostissa et al., J Biol Chem 2004*
• IRef Biogrid Interaction: TP53 — DAXX (direct interaction, pull down) Zhao et al., J Biol Chem 2004*
• IRef Biogrid Interaction: TP53 — DAXX (physical association, affinity chromatography technology) Tang et al., Nat Cell Biol 2006
• MIPS CORUM DAXX-Axin-p53-HIPK2 complex: DAXX-Axin-p53-HIPK2 complex complex (AXIN1-DAXX-HIPK2-TP53) Li et al., Cancer Res 2007*
• MIPS CORUM Daxx-Axin-p53 complex: Daxx-Axin-p53 complex complex (AXIN1-DAXX-TP53) Li et al., Cancer Res 2007*
• IRef Corum Interaction: Complex of AXIN1-DAXX-TP53 (association, anti tag coimmunoprecipitation) Li et al., Cancer Res 2007*
• IRef Corum Interaction: Complex of TP53-AXIN1-HIPK2-DAXX (association, anti bait coimmunoprecipitation) Li et al., Cancer Res 2007*
• IRef Hprd Interaction: TP53 — DAXX (in vitro) Kim et al., Nucleic Acids Res 2003*
• IRef Hprd Interaction: TP53 — DAXX (two hybrid) Kim et al., Nucleic Acids Res 2003*
• IRef Hprd Interaction: TP53 — DAXX (in vivo) Kim et al., Nucleic Acids Res 2003*
• IRef Intact Interaction: Complex of 13 proteins (association, anti tag coimmunoprecipitation) Zhao et al., J Biol Chem 2004*
• IRef Intact Interaction: Complex of 17 proteins (association, anti bait coimmunoprecipitation) Tang et al., Nat Cell Biol 2006
• IRef Intact Interaction: TP53 — DAXX (direct interaction, anti bait coimmunoprecipitation) Zhao et al., J Biol Chem 2004*
• IRef Intact Interaction: TP53 — DAXX (physical association, anti bait coimmunoprecipitation) Zhao et al., J Biol Chem 2004*
• IRef Intact Interaction: TP53 — DAXX (colocalization, fluorescence microscopy) Zhao et al., J Biol Chem 2004*
• IRef Intact Interaction: TP53 — DAXX (physical association, anti tag coimmunoprecipitation) Zhao et al., J Biol Chem 2004*
• IRef Intact Interaction: TP53 — DAXX (direct interaction, two hybrid) Zhao et al., J Biol Chem 2004*
• IRef Intact Interaction: Complex of TP53-DAXX (colocalization, fluorescence microscopy) Zhao et al., J Virol 2003*
• MIPS Negatome - no physical interaction between proteins Interaction: TP53 — DAXX (Absence of interaction, anti tag coimmunoprecipitation) Li et al., Cancer Res 2007*
• IRef Ophid Interaction: TP53 — DAXX (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Gostissa et al., J Biol Chem 2004 : Moreover, we show that hDaxx , which has been implicated in several apoptotic pathways, increases the sensitivity to DNA damage induced cell death and that this effect requires the presence of p53
Zhao et al., J Biol Chem 2004 : In p53/MDM2-null mouse embryonic fibroblasts ( DKO MEF ), Daxx repressed p53 target promoters whose p53 binding elements were required for the repression ... Importantly, posttranslational modifications of p53 inhibit Daxx-p53 interaction, thereby relieving negative regulation of p53 by Daxx
Li et al., Cancer Res 2007 : Daxx stimulated p53 transcriptional activity was significantly diminished by small interfering RNA against Axin ; Daxx fails to inhibit colony formation in Axin ( -/- ) cells
Yeung et al., J Cell Biochem 2008 : Finally, we show that nuclear localization of Daxx is essential for its transcriptional effects on GR and p53
Wethkamp et al., J Biol Chem 2011 : We provide evidence that the p53 recruitment into PODs is Daxx isoform dependent
Kumar et al., Oncogenesis 2013 : We show that Pdcd4 also disrupts the Daxx-Hipk2 interaction and inhibits the phosphorylation of p53