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BNIP3 — FOXO3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: BNIP3 → FOXO3 (directlyIncreases, BNIP3 Activity)
  Evidence: Following its dephosphorylation, FOXO3 translocates into the nucleus (Fig. 3A) and upregulates multiple autophagy-related genes such as ULK2, Beclin 1, VPS34, BNIP3 and BNIP3L, ATG12, ATG4B, LC3, and GABARAPL1 (Mammucari et al., 2007).

Text-mined interactions from Literome

Mammucari et al., Cell Metab 2007 (Muscular Atrophy) : FoxO3 controls the transcription of autophagy related genes, including LC3 and Bnip3, and Bnip3 appears to mediate the effect of FoxO3 on autophagy
Nath et al., J Clin Invest 2010 : Kume et al. demonstrated that caloric restriction protected the aging kidney by preserving renal Sirt1 expression, the latter deacetylating forkhead box O3a (FOXO3a) , inducing Bnip 3 , and promoting mitochondrial autophagy
Xu et al., Genes Dev 2011 : This autophagic response is caused by FoxO induced expression of Bnip3 that displaces the autophagic effector Beclin-1 from inactive Bcl-XL complexes
Reed et al., FASEB J 2012 (Cachexia...) : Expression of DN FoxO inhibited the increased mRNA levels of atrogin-1, MuRF1, cathepsin L, and/or Bnip3 and inhibited muscle fiber atrophy during cancer cachexia and sepsis