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EGF — PTHLH

Text-mined interactions from Literome

Tovar Sepulveda et al., Mol Cell Endocrinol 2002 (Prostatic Neoplasms) : 1,25 ( OH ) ( 2 ) D ( 3 ) reversed the EGF induced PTHrP upregulation at both the mRNA and protein levels
MacLeod et al., Biochem Biophys Res Commun 2004 : Inhibitors of matrix metalloproteinase and heparin bound-EGF prevented the CaR mediated increases of pERK and PTHrP , consistent with a `` triple-membrane spanning signaling '' requirement for transactivation of the EGFR by the CaR
Dvir et al., Eur J Endocrinol 1995 : The stimulation of PTHrP secretion by EGF or by hPL was both time- and dose dependent
Heath et al., Biochem J 1995 : EGF increased both PTHrP gene transcription and PTHrP mRNA stability ... Thus EGF regulation of PTHrP gene expression in HaCaT cells is multifactorial and the combination of its actions at the 5 ' and 3 ' ends of the gene favours the accumulation of subpopulations of PTHrP mRNA containing exons I, VII and VIII
Ferrari et al., J Bone Miner Res 1994 : We investigated the regulation of PTHrP production by epidermal growth factor (EGF) , a factor of major importance in the development of lactating breast, in primary cultures of rat mammary epithelial cells ... EGF stimulated the production of immunoreactive and bioactive PTHrP in a time- and concentration dependent manner ... These results indicate that EGF was capable of increasing the production of PTHrP by cultured mammary epithelial cells
Tait et al., Cancer 1994 (Carcinoid Tumor...) : TGF-beta 1 and EGF regulation of PTH-rP gene expression in squamous cell carcinomas of gynecologic origin is unique for each cell line studied and different from that in human lung carcinoid cells
Liu et al., Endocrinology 1993 (Hypercalcemia...) : Both fetal bovine serum and epidermal growth factor stimulated PTHRP gene expression and secretion into conditioned culture medium
Cramer et al., Prostate 1996 (Adenocarcinoma...) : Epidermal growth factor (EGF) was the major inducer of PTHrP expression, while cholera toxin, bovine pituitary extract, hydrocortisone, and insulin had minimal or no effect on PTHrP transcript levels ... Since each of these factors is growth stimulatory, the unique ability of EGF to induce PTHrP is apparently unrelated to mitogenicity
Falzon et al., Endocrinology 1996 (Osteosarcoma) : Insulin and epidermal growth factor also induced PTHrP mRNA expression in a time dependent manner analogous to serum, indicating that the effects of serum may be mediated, at least partially, through these agents
Falzon et al., Endocrinology 1998 (Lung Neoplasms) : This study was undertaken to determine whether 1,25-dihydroxyvitamin D3 [ 1,25- ( OH ) 2D3 ] and two nonhypercalcemic analogs, EB1089 and 22-oxa-1,25- ( OH ) 2D3 ( 22-oxacalcitriol ), suppress serum- and epidermal growth factor (EGF) induced PTHrP gene expression in a human lung squamous cancer cell line, NCI H520 ... PTHrP expression was up-regulated by serum and EGF in a concentration- and time dependent manner