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HMOX1 — USF2

Pathways - manually collected, often from reviews:

• NCI Pathway Database Validated transcriptional targets of AP1 family members Fra1 and Fra2: Fra1/USF2 complex (FOSL1-USF2) → HMOX1 (HMOX1) (transcription, inhibits) Samoylenko et al., Antioxid Redox Signal 2008*
  Evidence: reporter gene, physical interaction

Text-mined interactions from Literome

Hock et al., Biochem J 2004 : Furthermore, we show that overexpression of USF1 or USF2 enhances the basal expression of HO-1 and that expression of a USF dominant negative form reduces its expression
Samoylenko et al., Antioxid Redox Signal 2008 : We found that HO-1 expression was inhibited by USF-2 in primary cells, whereas it was induced in tumor cell lines ... Further, the USF dependent HO-1 promoter activity was not detectable with an USF-2 mutant lacking residues of the USF-specific region ( USR ) or the transactivation domain encoded by exon 4