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ANGPT2 — MAP2K1
Text-mined interactions from Literome
Aoki et al., Biochem J 2000
(Cardiomegaly) :
Although PD98059 and dominant negative
MEK1 blocked
Ang II-induced activation of the ANF promoter, SB203580 or dominant negative MEK kinase 1 (MEKK1) showed no effect
Li et al., J Appl Physiol 2004
(Anoxia) :
ANG II-induced PN expression was
blocked by the AT(1)-receptor antagonist losartan and by inhibitors of PI3K and
MEK1/2
Zhang et al., Arterioscler Thromb Vasc Biol 2005
(Vasculitis) :
Signaling distal to MEK1 involved extracellular signal regulated kinase ( ERK ) because inhibition of
MEK1 suppressed the
Ang II-induced activation of ribosomal S6 kinase ( RSK ), a substrate of ERK
Shimizu et al., FASEB J 2008
(Osteoporosis) :
Of importance,
Ang II significantly
induced the expression of receptor activator of NF-kappaB ligand ( RANKL ) in osteoblasts, leading to the activation of osteoclasts, whereas these effects were completely blocked by an Ang II type 1 receptor blockade ( olmesartan ) and
mitogen activated protein kinase kinase inhibitors
Abe et al., Hypertens Res 2008
:
DN-MEK1 markedly
inhibited Ang II-induced OPN promoter activity, while neither DN-JNK nor DN-p38 MAP kinase had any effect