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HIF1A — MMP1
Text-mined interactions from Literome
Luo et al., BJU Int 2006
(Neoplasm Invasiveness...) :
The expression of E-cadherin, vimentin, cathepsin D,
MMP-2 and uPAR, which are proteins with established roles in the pathophysiology of invasion, could be
regulated by
HIF-1alpha in human prostate cancer cells
Shyu et al., Exp Cell Res 2007
(Adenocarcinoma...) :
Mechanistic studies revealed that
HIF-1alpha overexpression could
increase the expression of uPAR and
MMP1 , but not MMP2
Lin et al., FEBS Lett 2008
(Osteoarthritis) :
Hypoxia-inducible factor-1alpha regulates
matrix metalloproteinase-1 activity in human bone marrow derived mesenchymal stem cells ... In vitro invasion assays and quantitative PCR analyses showed that targeted inhibition of HIF-1alpha in bmMSC-1 decreased its invasion and expressions of MMP1 and MMP3, whereas overexpression of
HIF-1alpha in bmMSC-5
increased its invasion and expressions of
MMP1 and MMP3 ... Therefore,
HIF-1alpha can
regulate MMP1 and MMP3 expressions in human bmMSCs, which might suggest a pathophysiological role of bmMSC expressing high HIF-1alpha in bone diseases
Kang et al., Clin Exp Pharmacol Physiol 2009
(Diabetes Mellitus, Experimental...) :
Impairment of ischaemia induced EPC mobilization in the diabetic mouse model is associated with altered
HIF-1 alpha/VEGF and
MMP/TIMP regulation and represents a novel mechanism underlying defective postischaemic neovascularization in diabetes