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IL8 — TGFB1

Text-mined interactions from Literome

Fujisawa et al., Placenta 2000 (Choriocarcinoma...) : In contrast to IL-6, the expression of IL-8 was not affected by TGF-beta1
Fong et al., Am J Physiol Lung Cell Mol Physiol 2000 : TGF-beta1 stimulates IL-8 release, COX-2 expression, and PGE ( 2 ) release in human airway smooth muscle cells ... In this study, we tested the ability of transforming growth factor (TGF)-beta1 to stimulate IL-8 release, cyclooxygenase (COX)-2 expression and PGE ( 2 ) generation in cultured human ASM cells and explored the role of COX products and COX-2 induction on IL-8 release ... These results show for the first time that TGF-beta1 stimulates IL-8 release, COX-2 induction, and PGE ( 2 ) generation in human ASM cells and that PGE ( 2 ) generation is not critical for TGF-beta1 induced IL-8 release
Wang et al., Inflamm Res 2001 : The differential effects of TGF-beta1 on IL-8 secretion from suspended and adherent cells could not be explained by differences in IL-1 receptor antagonist production
Kelley et al., Am J Respir Cell Mol Biol 2001 (Cystic Fibrosis...) : Our data demonstrate that both CF-phenotype cells lacking Smad3 expression, and A549 cells expressing a dominant negative Smad3, are unable to support TGF-beta1 mediated inhibition of either the interleukin (IL)-8 or the NOS2 promoter
Bry et al., Am J Obstet Gynecol 1992 (Obstetric Labor, Premature) : Human amnion cells in monolayer culture were treated with interleukin-1 , tumor necrosis factor, or vehicle in the presence or absence of transforming growth factor-beta
Wondergem et al., Atherosclerosis 2004 : Compared to cultures exposed to injury alone, radiation induced significant ( P < 0.05 ) increases in mRNA levels of IL-8 ( 1.35 +/- 0.10-fold increase at 4h ), FGF-2 ( 1.62 +/- 0.10-fold at 4h ; 1.76 +/- 0.33-fold at 24h ) and IL-1beta ( 2.76 +/- 0.40-fold at 24h ), whereas mRNA levels of TGF-beta1 , PDGF-A and PDGF-B increased about 1.2-fold
Méndez-Dávila et al., J Endocrinol Invest 2004 (Osteoporosis) : We investigated the effects of 17betaestradiol and two selective estrogen receptor modulators, tamoxifen and raloxifene, on the expression and release of constitutive and interleukin-1 stimulated interleukin (IL)-6, transforming growth factor-beta1 ( TGF-beta1 ) and insulin-like growth factor-1 by osteoblasts in primary culture from trabecular bone of healthy post-menopausal women
Liu et al., Cytokine 2005 (Melanoma) : Selective induction of interleukin-8 expression in metastatic melanoma cells by transforming growth factor-beta 1 ... We investigated the effects of TGF-beta1 on IL-8 expression in the well characterized A375 human melanoma system ... We demonstrated by enzyme linked immunoassay and Northern blot analysis that TGF-beta1 selectively induced IL-8 expression, at both protein and mRNA levels, in highly metastatic A375SM cells but not cells of their poorly metastatic parental line A375P ... Transient transfection with luciferase reporter gene constructs revealed that TGF-beta1 activated IL-8 promoter activity in A375SM cells but not A375P cells ... Studies with progressive 5 ' deletion constructs and site-specific mutations demonstrated that a construct containing -133 to +44 of the 5'-flanking sequence was necessary and sufficient for maximal TGF-beta1 induced transcription response and that TGF-beta1 induced activation of IL-8 promoter depended on AP-1 ( -126 to -120 bp ), NF-kappaB ( -94 to -71 bp ), and C/EBP-like factor NF-IL6 ( -94 to -81 bp ) in this region ... Our data thus demonstrated that TGF-beta1 selectively induced IL-8 expression in highly metastatic A375SM melanoma cells ... This TGF-beta1 induced IL-8 expression could be an amplification cascade responsible for overexpression of IL-8 in human melanoma and one of potential mechanisms by which TGF-beta1 promotes angiogenesis, growth, and metastasis of human melanoma
Qi et al., American journal of physiology. Renal physiology 2006 : TGF-beta1 induces IL-8 and MCP-1 through a connective tissue growth factor independent pathway ... TGF-beta(1) induced an increase in IL-8 and MCP-1 ( both P < 0.05 ) compared with control levels ... In the CTGF silenced cells, TGF-beta(1) stimulated IL-8 and MCP-1 secretion was not altered compared with control cells ... These data suggest that TGF-beta(1) induced IL-8 and MCP-1 via CTGF independent pathway
Charalambous et al., Cancer Res 2005 (Brain Neoplasms...) : Transforming growth factor-beta1 ( TGF-beta1 ), shown to down-regulate IL-8 production in BECs, does not inhibit IL-8 production in TuBECs
Lu et al., Prostate 2006 (Prostatic Neoplasms) : The purpose of this study was to investigate TGF-beta1 regulated IL-8 expression in prostate cancer cells ... TGF-beta1 regulated IL-8 expression was determined by real-time RT-PCR, enzyme linked immunoabsorbance assay ( ELISA ), nuclear run-on, and IL-8 promoter reporter assay ... The nuclear run-on and IL-8 luciferase reporter assays show that TGF-beta1 activated IL-8 gene transcription ... TGF-beta1 signaling regulates IL-8 expression in prostate cancer cells and may contribute to the overexpression of IL-8 in human prostate cancer
Qi et al., American journal of physiology. Renal physiology 2006 : We have recently demonstrated that TGF-beta(1) induces interleukin-8 (IL-8) , macrophage chemoattractant protein-1 ( MCP-1 ), and fibronectin production in renal proximal tubular ( HK-2 ) cells
Hosokawa et al., Clin Exp Immunol 2006 (Periodontitis) : The IL-8 and VEGF production induced by TWEAK was augmented synergistically by simultaneous stimulation with transforming growth factor (TGF)-beta1 or IL-1beta
Fong et al., J Bone Miner Res 2008 (Neoplasms) : In addition, TGF-beta1 also directly induced IL-8 release in human cancer cells ... Activation of AP-1 and NF-kappaB DNA-protein binding and MAPKs after TGF-beta1 treatment was shown, and TGF-beta1 induced IL-8 promoter activity was inhibited by the specific inhibitors of MAPK cascades
Layh-Schmitt et al., Curr Opin Rheumatol 2008 (Spondylarthropathies) : In mice, transforming growth factor-beta and interleukin-6 are critical, whereas interleukin-23 is more important at later stages promoting interleukin-17 production
Bekeredjian-Ding et al., Immunology 2009 (Head and Neck Neoplasms) : Here we demonstrate that tumour derived prostaglandin E2 ( PGE ( 2 ) ) and transforming growth factor-beta ( TGF-beta ) increase interleukin-8 (IL-8) but synergistically inhibit interferon-alpha ( IFN-alpha ) and tumour necrosis factor (TNF) production of Toll-like receptor 7 (TLR7)- and Toll-like receptor 9 (TLR9) stimulated PDC
Zenkel et al., Am J Pathol 2010 (Exfoliation Syndrome...) : IL-6 and IL-8 were significantly up-regulated by ciliary epithelial cells in response to hypoxia or oxidative stress in vitro, whereas IL-6, but not IL-8 , induced the expression of transforming growth factor-beta1 and elastic fiber proteins
Schuerer-Maly et al., Immunology 1994 : IL-4, IL-10 and transforming growth factor-beta ( TGF-beta ), which can down-regulate IL-8 production in macrophages, had no effect on IL-8 generation by our cell lines
Smith et al., J Immunol 1996 : Transforming growth factor-beta 1 inhibits the production of IL-8 and the transmigration of neutrophils through activated endothelium
Arici et al., J Clin Endocrinol Metab 1996 : As part of an investigation of the regulation of the leukocyte population of endometrium/decidua, this study was conducted to evaluate further the regulation of interleukin-8 (IL-8) gene expression by transforming growth factor-beta ( TGF beta )
Kumar et al., J Cell Physiol 1996 : Induction of interleukin-1 and interleukin-8 mRNAs and proteins by TGF beta 1 in rat lung alveolar epithelial cells ... Induction of interleukin-1 and interleukin-8 mRNAs and proteins by TGF beta 1 in rat lung alveolar epithelial cells ... In the current study, we sought to investigate whether TGF beta 1 induced the expression of IL-1 alpha and IL-8 in rat alveolar epithelial cells ... These results suggest that TGF beta 1 may regulate IL-1 alpha and IL-8 expression in alveolar epithelial cells and contribute to polymorphonuclear leukocyte recruitment and lung injury in clinical states with increased TGF beta 1
Hedges et al., Cytokine 1996 : IL-5, IL-12, IL-13 and TGF-beta 1 additively enhanced the bacterially induced IL-6 secretion, but they did not affect IL-8 secretion
Marth et al., Eur J Immunol 1997 : Regulation of transforming growth factor-beta production by interleukin-12
Gerritsma et al., Kidney Int 1998 (Kidney Diseases) : Transforming growth factor-beta 1 up-regulated IL-8 production by an average of 4.17 +/- 1.0 fold
Fulton et al., J Infect Dis 1998 : Regulation of interleukin-12 by interleukin-10, transforming growth factor-beta , tumor necrosis factor-alpha, and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra