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DDT — PTGS2
Text-mined interactions from Literome
Han et al., Toxicol Appl Pharmacol 2008
:
o,
p'-DDT induces
cyclooxygenase-2 gene expression in murine macrophages : Role of AP-1 and CRE promoter elements and PI3-kinase/Akt/MAPK signaling pathways ... Furthermore, o,
p'-DDT dose-dependently
increased the levels of
COX-2 protein and mRNA ... These results demonstrate that o,
p'-DDT induced
COX-2 expression via AP-1 and CRE activation through the PI3-K/Akt/ERK, JNK, and p38 MAP kinase pathways
Han et al., Toxicol Lett 2010
(Breast Neoplasms) :
In addition, o,
p'-DDT increased
COX-2 protein levels markedly, increased COX-2 mRNA expression and promoter activity, enhanced the production of prostaglandin E ( 2 ) ( PGE ( 2 ) ), induced cyclic AMP response element ( CRE ) activation, and cAMP levels and binding of CREB
Xin et al., Mol Cancer Res 2010
(Colorectal Neoplasms) :
The MIF homologue
D-dopachrome tautomerase promotes
COX-2 expression through ß-catenin dependent and -independent mechanisms ...
D-DT dependent
COX-2 transcription is mediated in part by ß-catenin protein stabilization and subsequent transcription