◀ Back to RELA
ATM — RELA
Pathways - manually collected, often from reviews:
-
BioCarta atm signaling pathway:
ATR/ATRIP/ATM complex (ATR-TREX1-ATM)
→
NF-kappa-B/I-kappa-B-alpha complex (NFKBIA-RELA)
(protein ubiquitination, activates)
-
BioCarta atm signaling pathway:
ATR/ATRIP/ATM complex (ATR-TREX1-ATM)
→
I-kappa-B-alpha/RELA/p50/ubiquitin complex (NFKBIA-RELA)
(protein ubiquitination, activates)
Text-mined interactions from Literome
Ashburner et al., Cancer Res 1999
(Ataxia Telangiectasia) :
Lack of
involvement of
ataxia telangiectasia mutated (ATM) in regulation of
nuclear factor-kappaB (NF-kappaB) in human diploid fibroblasts
Sharma et al., Bioorg Med Chem 2000
:
The metal-interaction of
aurine tricarboxylic acid (ATA) and its inhibitory
effect on the DNA binding of
NFkappaB were studied
Tsi et al., Mol Pharmacol 2002
:
ATA not only
inhibited nuclear factor-kappaB (NF-kappaB) activation through impairment of the targeting and degradation of IkappaBs but also reduced LPS induced activator protein-1 (AP-1) activation
Marchisio et al., Int J Immunopathol Pharmacol 2004
:
Apoptosis effected by TNF-alpha alone was suppressed by
ATA and this event was
paralleled by phosphorylation and nuclear translocation of Jak2, Stat2, Stat4 and
NF-kB , along with inhibition of caspase activation