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RELA — STAT1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Nomura et al., Toxicol Lett 1998
(Ischemic Attack, Transient) :
LPS caused intranuclear translocation of
NF-kappaB , and IFNgamma
induced phosphorylation of Jak2 and
Stat1 , followed by the translocation of Stat1 into the nucleus
Ohtsubo et al., J Cell Physiol 2000
(Carcinoma, Squamous Cell) :
These observations suggest the
activation of
NFkappaB via IkappaB degradation and
STAT1 via specific receptor kinase activity synergistically induce WAF1 gene expression in A431 cells
Wang et al., Mol Cell Biol 2000
:
As a consequence, TNF-alpha mediated I-kappaB degradation and
NF-kappaB activation were markedly
enhanced in Stat1-deficient cells, whereas overexpression of
Stat1 in 293T cells blocked NF-kappaB activation by TNF-alpha
Mukhopadhyay et al., J Cell Biochem 2002
:
STAT1 was, however,
required for IFNalpha mediated downregulation of TNF induced
NF-kappaB activation
Richardson et al., J Virol 2003
(Cell Transformation, Viral) :
The increase in STAT1 expression is mediated by the C-terminal activating region 1 ( CTAR-1 ) and/or CTAR-2 domains of LMP-1 and is inhibited by mutant IkappaB, demonstrating a
role for
NFkappaB in LMP-1 mediated
STAT1 expression
Rothfuchs et al., J Immunol 2004
:
Such
NF-kappaB activation was
independent of IFN-alphabeta,
STAT1 , and RNA dependent protein kinase
Najjar et al., J Virol 2005
(Burkitt Lymphoma...) :
Inhibition of
NF-kappaB activity by different pharmacological inhibitors ( i.e., parthenolide, MG132 and BAY 11-7082 ) and by overexpressed mutated IkappaBalpha
prevented the activation of
STAT1
Choi et al., J Neurosci Res 2005
(Alcohol-Induced Disorders, Nervous System...) :
Lipopolysaccharide (LPS), gangliosides, and interferon (IFN)-gamma induced the inflammatory activation of glia, which was differentially influenced by ethanol : 1 ) ethanol inhibited LPS- or gangliosides induced, but not IFNgamma induced, glial activation as demonstrated by the production of nitric oxide and the expression of inflammatory genes such as interleukin-1beta, tumor necrosis factor-alpha, IP-10, and CD86 ; 2 )
nuclear factor (NF)-kappaB or JAK/STAT1 pathway was necessary for LPS- or IFNgamma induced glial activation, respectively ; 3 ) ethanol inhibited LPS induced NF-kappaB activation ; and 4 ) ethanol did not significantly
affect IFNgamma induced
STAT1/IRF-1 activation
Ganster et al., J Interferon Cytokine Res 2005
(Inflammation) :
IFN-gamma and
Stat1 dependent inhibition of
NF-kappaB transcription occurs independent of TNF-alpha induced NF-kappaB DNA binding
Kårehed et al., Mol Immunol 2007
:
Our results suggest that IFN-gamma induced increase of FcgammaRI expression requires the integration of two signalling events : PKR dependent
Stat1 serine 727 phosphorylation, and
activation of
NFkappaB
Ishiguro et al., Toxicol Appl Pharmacol 2006
(Colitis) :
Furthermore, Paeonol reduced TNFalpha induced
NF-kappaB transactivation and IFNgamma induced
STAT1 transactivation in CW-2 cells and also in Jurkat cells
Lee et al., J Leukoc Biol 2007
:
IFN-gamma induced CD40 expression involves activation of
STAT-1alpha as well as
NF-kappaB activation through an autocrine response to IFN-gamma induced TNF-alpha production
Hayashi et al., J Immunol 2007
(Acute Disease...) :
In comparison with WT mice, IFN-gamma ( -/- ) mice exhibited exaggerated and prolonged NF-kappaB activation, probably due to reduced acetylation of Stat1, a main signal transducer of IFN-gamma, because acetylated
Stat1 can
inhibit NF-kappaB activation
Kanda et al., Endocrinology 2008
:
IL-1beta
enhanced the transcriptional activity of
NF-kappaB , whereas leptin enhanced
STAT1 and STAT3 activity
Ghosh et al., Chem Biol Interact 2009
(Disease Models, Animal...) :
Investigating the cell signaling pathways, we found that the protein exerts its protective action via the
activation of
NF-kappaB and Akt and deactivation of
STAT-1
Cantrell et al., Immunobiology 2010
(Melanoma, Experimental) :
Activation of both cell types is associated with the induction of the MAP kinase pathway, the phosphorylation of
STAT1 , STAT5 and AKT and with transcription factor
NF-kappaB activation in vitro and in vivo
Wan et al., Nucleosides Nucleotides Nucleic Acids 2010
:
Exposure to IFN-gamma mainly affects nuclear IRF-1 and
STAT1 in EMT6, but
inhibits NF-kappaB p65 activity, indicating that the cooperative stimulation was the result of the independent activation of NF-kappaB, STAT1 and IRF-1 transcriptional factors through binding to their unique sites in the UPase promoter
Zhang et al., Virology 2013
:
Additionally, PKR silencing suppressed NF-kB activation and
NF-kB mediated
STAT1 phosphorylation in Huh7.5.1 cells and HCV1a persistently infected Huh7.5.1 cells ( 2HDD4 )
Nguyen et al., Oncogene 1997
:
Most strikingly, induction of IRF-1 and
IRF/RelA expression
resulted in a significant increase in
STAT1 ( p91 ) protein and increased ISGF3 DNA binding activity, suggesting that IRF-1 tumor suppressor activity may involve a novel mechanism which activates the JAK-STAT pathway through STAT1
Agresti et al., Eur J Neurosci 1998
:
The existence of a synergism between IFN-gamma and TNF-alpha in stimulating IRF-1 expression at the transcriptional level was supported by IRF-1 promoter analysis : IFN-gamma directly
induced the binding of
STAT-1 homodimers to the GAS element, while
NF-kappaB binding to the kappaB sequence was activated by TNF-alpha only after IFN-gamma treatment