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CDC25B — CDK2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CDC25B — CDK2 (direct interaction, enzymatic study) Cheng et al., BMC biochemistry 2005*
• IRef Biogrid Interaction: CDC25B — CDK2 (direct interaction, two hybrid) Conklin et al., Proc Natl Acad Sci U S A 1995*
• IRef Intact Interaction: CDC25B — CDK2 (physical association, two hybrid) Zariwala et al., Oncogene 1998

Text-mined interactions from Literome

Mitra et al., Oncogene 2004 : Cdk2-dn induction could inhibit Cdc25B activity and foster Cdk1 tyr phosphorylation within the S phase, temporally dissociating these events from Cdk1 activation at mitosis
Major et al., Mol Cell Biol 2004 (MAP Kinase Signaling System) : Likewise, Cdc25B mediated stimulation of Cdk activity together with elevated levels of the CBP coactivator protein provided a 6.2-fold synergistic increase in FoxM1B transcriptional activity
Varmeh et al., J Biol Chem 2009 : Forced expression of Cdc25B inappropriately up-regulated the activity of Cdk1 and Cdk2 , by reducing levels of inhibitory phosphorylation