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NPPA — S100A12

Text-mined interactions from Literome

Piao et al., Eur J Pharmacol 2004 : This study aimed to investigate the effect of CGRP on atrial hemodynamics and atrial natriuretic peptide (ANP) release by using isolated perfused beating left atria and to identify its receptor subtypes ... Rat alpha-CGRP ( 0.1, 1, 10, or 100 nM ) increased atrial contractility and suppressed the release of ANP in a concentration dependent manner ... Pretreatment with a receptor antagonist for CGRP ( 1 ) [ rat alpha-CGRP- ( 8-37 ) ] blocked rat alpha-CGRP induced suppression of ANP release and positive inotropism, whereas the antagonists for salmon or amylin did not ... Therefore, we suggest that rat alpha-CGRP causes a suppression of ANP release with positive inotropism through the receptor for CGRP ( 1 ) but not that for calcitonin and amylin
Nakayama et al., J Pharmacol Exp Ther 2007 (Reperfusion Injury...) : ANP increased CGRP release and cellular cAMP levels in dorsal root ganglion neurons isolated from rats in vitro ... The increase in CGRP release induced by ANP was reversed by pretreatment with capsazepine, an inhibitor of vanilloid receptor-1 activation, or with ( 9S, 10S, 12R ) -2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo [ 1,2,3-fg : 3',2',1'-kl ] pyrrolo [ 3,4-i ] [ 1,6 ] -benzodiazocine-10-carboxylic acid hexyl ester ( KT5720 ), an inhibitor of protein kinase A (PKA), suggesting that ANP might increase CGRP release from sensory neurons by activating PKA through an increase in the cellular cAMP level
Schiebinger et al., Endocrinology 1989 (Second Messenger Systems) : We, therefore, examined the effect of CGRP on immunoreactive ANP ( ANP-IR ) secretion ... A biphasic 2-fold increase in ANP-IR secretion occurred in response to CGRP ... The biphasic ANP-IR secretory response to CGRP was similar to that induced by superfusion with the beta-adrenergic agonist isoproterenol and ( Bu ) 2cAMP, but distinct from that of the non-cAMP dependent stimuli phenylephrine, ouabain, and Bay K 8644
Yamamoto et al., Biochem Biophys Res Commun 1988 : The effect of calcitonin gene related peptide(CGRP) on the release of atrial natriuretic peptide(ANP) was studied in spontaneously beating, isolated rat atria ... CGRP stimulated the ANP release in a dose dependent manner ... Therefore, we conclude that CGRP stimulates ANP release as well as cardiac contractility independently of adrenergic and cholinergic receptors
Helin et al., Life Sci 1994 (Heart Failure) : After SCH 34826, plasma CGRP-ir decreased marginally in CHF rats ( 57- > 51 ng/l, p = 0.011 ), and ANP increased 1.8-fold ( 418- > 730 ng/l, p = 0.001 )