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CDK4 — RELA

Text-mined interactions from Literome

Chandramohan et al., J Immunol 2004 : B cell receptor (BCR) engagement of murine WEHI 231 immature B lymphoma cells leads sequentially to a drop in NF-kappa B and c-Myc, and induction of the p27 ( Kip1 ) cyclin dependent kinase inhibitor, which promotes growth arrest and apoptosis
Thoms et al., Cancer Res 2007 (Colorectal Neoplasms...) : Furthermore, chemical inhibition of the cyclin D1/cyclin dependent kinase 4 (CDK4) kinase complex, used as a surrogate for cyclin D1 degradation, caused nucleolar translocation of RelA , repression of kappaB-driven transcription, and apoptosis, thereby reproducing the effects of aspirin ... In addition, we found that aspirin and the CDK4 inhibitor induced nucleolar translocation of RelA and apoptosis through a common mechanism involving the NH ( 2 ) -terminal nucleolar localization signal
Thoms et al., Cell cycle (Georgetown, Tex.) 2007 (Adenocarcinoma...) : Specific inhibition of CDK4 activity induced translocation of RelA , the principal component of NFkappaB, from the cytoplasm to the nucleoplasm and then to the nucleolus
Lee et al., American journal of physiology. Renal physiology 2008 : Consequently, the inhibition of Ca ( 2+ ), PKC, EGFR, p44/42 MAPKs, or NF-kappaB blocked the BSA induced increases in cyclin D1, cyclin dependent kinase (CDK)4, cyclin E, or CDK2 and restored the BSA induced inhibition of p21 ( WAF/Cip1 ) and p27 ( Kip1 ) expression ... Consequently, the inhibition of Ca ( 2+ ), PKC, EGFR, p44/42 MAPKs, or NF-kappaB blocked the BSA induced increases in cyclin D1, cyclin dependent kinase (CDK)4 , cyclin E, or CDK2 and restored the BSA induced inhibition of p21 ( WAF/Cip1 ) and p27 ( Kip1 ) expression