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BRCA1 — E2F1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: BRCA1 — E2F1 Wang et al., Oncogene 1997
• IRef Bind_translation Interaction: BRCA1 — E2F1 (experimental interaction detection) Wang et al., Oncogene 1997
• IRef Bind_translation Interaction: BRCA1 — E2F1 (affinity chromatography technology) Wang et al., Oncogene 1997
• IRef Biogrid Interaction: BRCA1 — E2F1 (physical association, affinity chromatography technology) Gorski et al., Nucleic Acids Res 2011*
• IRef Dip Interaction: BRCA1 — E2F1 (physical association, fluorescence microscopy) Liu et al., Mol Cell Biol 2003
• IRef Hprd Interaction: BRCA1 — E2F1 (in vivo) Hashizume et al., J Biol Chem 2001*, Wang et al., Oncogene 1997
• IRef Hprd Interaction: BRCA1 — E2F1 (in vitro) Hashizume et al., J Biol Chem 2001*, Wang et al., Oncogene 1997
• IRef Innatedb Interaction: Complex of 13 proteins (unknown, -) Bindra et al., Cancer Res 2005*
• IRef Innatedb Interaction: BRCA1 — E2F1 (unknown, -) Bindra et al., Cancer Res 2005*
• IRef Ophid Interaction: BRCA1 — E2F1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Wang et al., J Biol Chem 2000 (Breast Neoplasms...) : Moreover, ectopic expression of cyclin D1 and Cdk4 can stimulate the Brca1 promoter in an E2F dependent manner, and this is inhibited by coexpression of the p16(INK4a) cyclin dependent kinase inhibitor ... The human BRCA1 promoter also contains a conserved E2F site and is similarly regulated by E2F1 and Rb
Bindra et al., Cancer Biol Ther 2006 (Breast Neoplasms...) : We have shown recently that the tumor microenvironmental stress of hypoxia induces an E2F dependent repression of BRCA1 in cancer cells