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CD40LG — IFNG

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: IFNG → CD40LG (increases) Yu et al., J Immunol 2003*
  Evidence: Treatment of immature monocyte-derived dendritic cells (iMDDCs) with a combination of all three TNF family molecules did not always enhance CTL responses (activity was measured by checking the increase in intracellular IFN gamma production) above those with CD40LT treatment alone. Thus, CD40LT, TNF-alpha, or RANKLT conditioning of iMDDCs could expand HIV-1-specific memory CTL with the greatest expansions observed with CD40LT.
• OpenBEL Selventa BEL large corpus: IFNG → CD40LG (increases)
  Evidence: CD40L induces expression of tumor necrosis factor-a, interferon-g, IL-1, IL-6, and IL-8 in peripheral blood monocytes [71,72]
• OpenBEL Selventa BEL large corpus: CD40LG → IFNG (increases)
  Evidence: proinflammatory cytokines, such as IL-1, IL-12, TNF-, or IFN-, as well as glucocorticoids, induce expression of the ligand in T lymphocytes,
• OpenBEL Selventa BEL large corpus: CD40LG → IFNG (increases)
  Evidence: IFN-, a cytokine expressed early during atherogenesis, potently induces CD40/CD40L expression.7?11

Text-mined interactions from Literome

Subauste et al., J Immunol 1999 (Chronic Disease...) : CD40-CD40L signaling was required for optimal T cell production of IFN-gamma in response to T. gondii
Méndez-Samperio et al., Scand J Immunol 1999 : Furthermore, the presence of a trimeric soluble CD40L agonist (CD40T) in cultures increased the production of IL-12 and IFN-gamma
Marovich et al., J Immunol 2000 (Leishmaniasis, Cutaneous) : Finally, DC generated from mononuclear cells from patients with cutaneous leishmaniasis ( Lm ), once loaded with live metacyclic promastigotes, were found to reactivate autologous primed T lymphocytes and induce a CD40L dependent IFN-gamma response
Mishra et al., Proc Natl Acad Sci U S A 2001 (Lupus Erythematosus, Systemic) : This reversal corrected the aberrant expression of these gene products, thereby enhancing IFN-gamma production and inhibiting IL-10 and CD154 expression
Mendel et al., J Neuroimmunol 2002 (Disease Models, Animal...) : We demonstrate that the proliferative response and IFN-gamma production by a fully differentiated T cell line specific for myelin oligodendrocyte glycoprotein are completely independent of IL-12 and CD40/CD40L interactions
Subauste et al., J Infect Dis 2004 (AIDS-Related Opportunistic Infections...) : Recombinant CD154 partially restored secretion of IL-12 and IFN-gamma in response to T. gondii in cells from HIV infected patients
Kaufman et al., J Immunol 2004 (Pulmonary Fibrosis) : Interestingly, CD40L expression is down-regulated by IFN-gamma , a type 1 cytokine with antiscarring properties, and is up-regulated by the profibrogenic type 2 cytokine IL-13 ... Moreover, the antifibrotic activity of IFN-gamma may involve the down-regulation of fibroblast CD40L levels
Jeurissen et al., Eur J Immunol 2004 (Hypergammaglobulinemia) : Furthermore, we showed that caps-PS induce production of IL-4, IL-6, IL-10, and IFN-gamma , and that this enhanced production was inhibited by blocking the CD40-CD40L interaction
Scott et al., Clin Exp Immunol 2004 (Sepsis) : CD40-CD154 interactions between macrophages and natural killer cells during sepsis are critical for macrophage activation and are not interferon gamma dependent
Atochina et al., Clin Diagn Lab Immunol 2005 : As part of the cell-cell contact mechanism, we determined that CD40-CD40L interaction was critical for IFN-gamma secretion by NK cells, as the addition of anti-CD40L antibodies to the coculture blocked IFN-gamma production
Geraldes et al., Cardiovasc Res 2006 : Treatment of PAEC with antisense oligomers targeting ERalpha mRNA attenuated the ability of 17betaE to inhibit the IFN-gamma induced CD40 and CD40L protein expression ... In summary, 17betaE binding to ERalpha blocked IFN-gamma induced Stat1 phosphorylation, CD40 and CD40L protein expression, and neutrophil adhesion onto ECs
Hewitson et al., J Immunol 2006 (Helminthiasis) : CD40/CD154 interactions are required for the optimal maturation of skin derived APCs and the induction of helminth-specific IFN-gamma but not IL-4 ... The presence of CD154 was important for optimal IL-12p40 and essential for Ag-specific IFN-gamma , but CD154 expression by wild-type CD4- cells was insufficient to rescue recall responses of CD4+ cells from CD154-/- mice
Reddy et al., Cell Immunol 2007 : CNTO 1275 inhibited upregulation of CLA, IL-12R, IL-2Ralpha and CD40L expression and also inhibited IL-12- and IL-23 induced IFN-gamma , IL-17A, tumor necrosis factor (TNF)-alpha, IL-2, and IL-10 secretion
Tomihara et al., Gene Ther 2008 (Carcinoma, Squamous Cell...) : Gene transfer of CD40-ligand to dendritic cells stimulates interferon-gamma production to induce growth arrest and apoptosis of tumor cells
Li et al., Int Immunopharmacol 2009 (Atherosclerosis) : We found that DHEA inhibited IFN-gamma induced expression of CD40 and CD40L in a dose dependent manner
Tuettenberg et al., Exp Dermatol 2010 : Furthermore, stimulation of CD8 ( + ) T cells by peptide loaded CD40L-DC resulted in a substantial reduction of antigen-specific IFN-gamma production
Bihl et al., J Immunol 2010 (Leishmaniasis, Cutaneous) : We show that early IFN-gamma secretion by NK cells is controlled by IL-2 and IL-12 and is dependent on CD40/CD40L interaction
Ramsdell et al., J Immunol 1994 : In addition to proliferation, CD40L induces lectin mediated cytolytic activity in thymic gamma delta T cells as well as the production of IFN-gamma and TNF-alpha
Peng et al., Eur J Immunol 1996 : In this study we demonstrate that upon stimulation of human peripheral blood T cells through the T cell receptor (TCR)/CD3 complex, CD40/CD40L interaction strongly enhances the production of Th1 cytokines such as interleukin (IL)-2 and interferon (IFN)-gamma and Th2 cytokines such as IL-4, IL-5 and IL-10 by a direct effect on T cells
Macaulay et al., J Immunol 1997 : These results suggest that B cells activated by their cognate Ag preferentially induce IL-4 synthesis as a result of the interaction of CD40L on T cells with CD40, whereas SAC preferentially induce IFN-gamma synthesis by T cells as a result of their greater production of IL-12 and their limited capacity to trigger CD40L on T cells
McDyer et al., J Immunol 1998 : CD40 ligand/CD40 stimulation regulates the production of IFN-gamma from human peripheral blood mononuclear cells in an IL-12- and/or CD28 dependent manner ... The enhancement of IFN-gamma production induced by direct CD28 stimulation was primarily dependent on endogenous IL-12 or CD40L/CD40 stimulation
Chougnet et al., Eur J Immunol 1998 (HIV Infections...) : IL-12 production was not altered by CD40L alone, was increased by IFN-gamma , and was synergistically restored to normal values by IFN-gamma + CD40L
Hirohata et al., Clin Exp Immunol 1999 : Exogenous interferon-gamma (IFN-gamma) did not increase CD40L expression on immobilized anti-CD3 stimulated CD4+ T cells at any time up to 168 h of culture
Von Beust et al., Vaccine 1999 : Biologically active bovine IL4 expressed by vaccinia virus stimulated lymphoblast proliferation, B lymphocyte proliferation in the presence of CD40L , and inhibited IFN gamma secretion from PHA activated PBMC in a dose dependent fashion