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CHGA — IFNG
Text-mined interactions from Literome
Pavlovic et al., Eur Cytokine Netw 1999
:
IFN-gamma decreased the IL-1beta induced SPI-3 expression in wt islets or beta-cells, but induced a 5-fold increase in the expression of this mRNA in IRF-1-/- islets cells, suggesting that IRF-1 mediates an inhibitory
effect of
IFN-gamma on
SPI-3 expression
Hamerman et al., J Immunol 2002
(Bacterial Infections) :
The cytokine
IFN-gamma also
induces spi2a expression in macrophages, and this induction is synergistic with bacterial products ... Whereas
spi2a was
induced by either bacterial products or
IFN-gamma , ISG15 was induced only by bacterial products
Kordula et al., Biochem J 1995
:
Thus the
induction of the
SPI-3 gene by
IFN gamma correlates with the binding of Stat1 to a specific element which, in turn, binds Stat3 in response to interleukin 6