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MYLIP — TNF
Text-mined interactions from Literome
Tili et al., J Immunol 2007
(Shock, Septic) :
Modulation of
miR-155 and miR-125b levels
following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock ... Altogether, our data suggest that the
LPS/TNF-alpha dependent regulation of
miR-155 and miR-125b may be implicated in the response to endotoxin shock, thus offering new targets for drug design
Stanczyk et al., Arthritis Rheum 2008
(Arthritis, Rheumatoid) :
Constitutive expression of both miR-155 and miR-146a was higher in RASFs than in those from patients with osteoarthritis ( OA ), and expression of
miR-155 could be further
induced by
TNFalpha , interleukin-1beta, lipopolysaccharide, poly ( I-C ), and bacterial lipoprotein
Jones et al., Osteoarthritis Cartilage 2009
(Osteoarthritis, Knee) :
Over-expression of miR-9, miR-98 or
miR-146 in isolated human chondrocytes reduced interleukin-1 beta (IL-1 beta)
induced TNF-alpha production
Suárez et al., J Immunol 2010
(Inflammation) :
Specifically, E-selectin and ICAM-1 are targets of
TNF induced miRNAs
miR-31 and miR-17-3p, respectively
Cho et al., J Cell Physiol 2010
(Calcinosis) :
Overexpression of
miR-146a induced the inhibition of IRAK1 expression and inhibited basal and
TNF-alpha- and TLR ligand
induced osteogenic differentiation
Roggli et al., Diabetes 2010
(Inflammation) :
We found that IL-1beta and
TNF-alpha induce the expression of
miR-21 , miR-34a, and miR-146a both in MIN6 cells and human pancreatic islets
Guo et al., Immunol Cell Biol 2010
(Acute Coronary Syndrome...) :
In addition, this study also provided evidence that
miR-146a treatment in vitro could
induce the protein expression of
TNF-alpha , MCP-1, NF-kappaB p65, which are key pro-inflammatory cytokines and critical transcription factor in AS
El Gazzar et al., J Biol Chem 2010
(Inflammation...) :
Functional inhibition of
miR-221 prevented
TNFalpha mRNA degradation, and blocking miR-579 and miR-125b precluded translation arrest
Nahid et al., J Immunol 2011
(Bacteroidaceae Infections...) :
Transfection of
miR-146a into THP-1 cells
caused reduction of
TNF-a production, mimicking LPS induced cross-tolerance
Semaan et al., PloS one 2011
(Arthritis, Rheumatoid) :
Interestingly, transfection of
miR-346 in LPS activated THP-1 cells
inhibited TNF-a secretion ... Conversely, transfection of
miR-346 in LPS activated THP-1 cells increased TTP mRNA expression and
inhibited TNF-a release ... These results indicate that
miR-346 controls
TNF-a synthesis by regulating TTP expression
Culpan et al., International journal of molecular epidemiology and genetics 2011
:
TNFA expression was similar in AD and control brains but
miR-128a/b levels were significantly
reduced in the temporal cortex and miR-128b in the frontal cortex in AD
Kurowska-Stolarska et al., Proc Natl Acad Sci U S A 2011
(Arthritis, Experimental...) :
Conversely, inhibition of
miR-155 in RA synovial CD14 ( + ) cells
reduced TNF-a production
Ye et al., Gastroenterology 2011
:
Transfection of enterocytes with an antisense oligoribonucleotide against miR-122a blocked the
TNF-a induced increase in enterocyte expression of
miR-122a , degradation of occludin mRNA, and increase in intestinal permeability
Rajaram et al., Proc Natl Acad Sci U S A 2011
(MAP Kinase Signaling System) :
In contrast, SmegLM and live M. smegmatis
induce high
miR-155 expression and low miR-125b expression with high
TNF production
Gong et al., Cancer Sci 2012
(Carcinoma, Hepatocellular...) :
Among them, miR-30c-1 ( * ) was noticed because overexpression of
miR-30c-1 ( * )
triggered upregulation of transmembrane
tumor necrosis factor-a expression and enhanced NK cell cytotoxicity against hepatoma cell lines SMMC-7721 and HepG2
Chan et al., Arterioscler Thromb Vasc Biol 2012
(Diabetes Mellitus...) :
In mice with diabetes mellitus, excessive
tumor necrosis factor-a induced
miR-200b blunting proangiogenic functions of GATA2 and VEGFR2
Bala et al., International journal of hepatology 2012
:
Induction of
miR-155 contributed to increased
TNF alpha production and to the sensitization of KCs to produce more TNF alpha in response to LPS
Wu et al., Bone 2012
(MAP Kinase Signaling System) :
Furthermore,
miR-155 expression could be
induced by
TNF-a through the JNK pathway
Jude et al., Am J Physiol Lung Cell Mol Physiol 2012
(Asthma...) :
Basal and
TNF-a induced expression of
miR-140-3p was determined in nonasthmatic ASM ( NAASM ) and asthmatic ASM ( AASM ) cells ...
TNF-a attenuated
miR-140-3p expression in NAASM and AASM cells, but at a greater magnitude in AASM cells
Zhang et al., Journal of neuroinflammation 2012
(Anoxia...) :
Our data suggest a potential
role for
miR-181c in the regulation of
TNF-a expression after ischemia/hypoxia and microglia mediated neuronal injury
Wu et al., J Lipid Res 2012
(Hyperlipidemias) :
Abundance of
miR-181a attenuated ox-LDL induced CD83 and CD40 expression,
inhibited the secretion of interleukin (IL)-6 and
TNF-a , and up-regulated IL-10, an important anti-inflammatory cytokine that was inhibited by ox-LDL
Iyer et al., PloS one 2012
(Brain Diseases...) :
Modulation of
miR-146a expression
affected also the release of several cytokines such as IL-6 and
TNF-a
Kanaan et al., Innate Immun 2013
(Chronic Disease...) :
TNF-a ,
regulated by
miR-155 and miR-146a, was decreased in the LPS pretreated group at all time points ( P? < ?0.05 ), as were HMGB1, a key alarmin regulated by miR-146, -142-3p, -299 and -200c ( P? < ?0.05 ), and IL-1ß and IL-6, both regulated by miR-132and miR-21 respectively ( P? < ?0.05 )
Yang et al., J Bone Miner Res 2013
:
miR-21 was
suppressed by
TNF-a during the osteogenesis of MSCs
Sun et al., Hypertension 2012
:
Moreover, we observed that simvastatin attenuated
tumor necrosis factor-a induced upregulation of
miR-155 and ameliorated the effects of tumor necrosis factor-a on eNOS expression and endothelium dependent vasodilation
Xu et al., Mol Biol Rep 2013
(Obesity) :
Tumor necrosis factor-a (TNF-a) , leptin and resistin, but not interleukin-6,
caused downregulation of
hsa-miR-26b expression in adipocytes ... These results suggest that the expression of
hsa-miR-26b is
affected by
TNF-a , leptin and resistin and that hsa-miR-26b may be an important mediator in regulating the obesity related insulin sensitivity and inflammatory responses
Jin et al., Cancer Res 2013
(Breast Neoplasms...) :
Also, we report for the first time that HER2/neu ( ERBB2 ), EGF, and
TNF-a promote
miR-23b/27b expression through the AKT/NF-?B signaling cascade
Shi et al., Glia 2013
(Inflammation...) :
The overexpression of
miR-195 contributed to lipopolysaccharide induced expression of proinflammatory cytokines IL-1ß,
TNF-a , and iNOS in cultured microglia
Kutty et al., Molecular vision 2013
:
Our results clearly show that both
miR-146a and miR-146b-5p are expressed in human RPE cells in culture and their expression is highly
induced by proinflammatory cytokines ( IFN-? +
TNF-a + IL-1ß )
Motohashi et al., J Cell Sci 2013
:
Moreover, our results demonstrate that
miR-128a expression levels are negatively
controlled by
tumor necrosis factor a (TNF-a)
Zhao et al., Stroke 2013
(Brain Ischemia...) :
Meanwhile, lentiviral overexpression of
miR-424 inhibited neuronal apoptosis and microglia activation, including suppressing ionized calcium binding adaptor molecule-1 immunoreactivity and protein level, and reduced
tumor necrosis factor-a production
Hutchison et al., Glia 2013
:
Knockdown of miR-181
enhanced LPS induced production of pro-inflammatory cytokines (
TNF-a , IL-6, IL-1ß, IL-8 ) and HMGB1, while overexpression of
miR-181 resulted in a significant increase in the expression of the anti-inflammatory cytokine IL-10
Chen et al., Biochem Pharmacol 2013
(Leukemia) :
Hydroquinone induced
miR-122 down-regulation elicits ADAM17 up-regulation,
leading to increased soluble
TNF-a production in human leukemia cells with expressed Bcr/Abl
Chen et al., Scand J Gastroenterol 2013
(Colitis, Ulcerative) :
Further, we observed that
miR-19a directly
regulated TNF-a expression because miR-19a can suppress the expression of wild-type TNF-a reporter, but not the mutant form ... Taken together, this study determines the levels of miR-19a and TNF-a in both DSS induced experimental murine colitis and human UC and further demonstrates that
miR-19a might directly
regulate TNF-a