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ICAM1 — STAT1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Coccia et al., Int Immunol 1999
:
Taken together these results indicate that
STAT1 plays a pivotal role in the differentiation/maturation process of monocytes as an early transcription factor initially activated by adherence and then able to
modulate the expression of functional genes, such as
ICAM-1 and FcgammaRI
Kim et al., Mol Pharmacol 2001
:
MMI
inhibits transcription of the
intercellular adhesion molecule-1 ( ICAM-1 ) gene by modulating the function of transcription factor
STAT1 ( signal transducer and activator of transcription 1 ), which binds to the IFN-gamma activated site of the ICAM-1 promoter
Mazzarella et al., Am J Pathol 2003
(Celiac Disease) :
Furthermore, inhibition of
STAT-1 prevented the gliadin mediated induction of
ICAM-1 and B7-2
Chang et al., Mol Pharmacol 2004
:
Differential role of Janus family kinases ( JAKs ) in interferon-gamma induced lung epithelial
ICAM-1 expression :
involving protein interactions between JAKs, phospholipase Cgamma, c-Src, and
STAT1 ...
ICAM-1 promoter activities induced by the overexpression of wild-type JAK1- and PLC-gamma2 were
blocked by the PLCgamma2 mutant or the dominant negative PKCalpha ( Lys -- > Arg ), c-Src ( Lys -- > Met ), or
STAT1 ( Y701M ) mutants, but not by dominant negative STAT3 ( DN ) mutants
Profita et al., J Pharmacol Exp Ther 2008
:
In conclusion, for the first time, we provide evidence of the involvement of STAT-1 in the signal transduction mechanism of the CysLT ( 1 ) receptor ; phosphorylation of
STAT-1 , through PKC and ERK1/2 activation,
causes enhanced
ICAM-1 surface expression and eosinophil adhesion
Tang et al., Am J Nephrol 2010
(Diabetes Mellitus, Type 2...) :
In addition, Ros but not metformin attenuated renal cortical expression of CCL2, MIP-2, and
ICAM-1 and
inhibited p-STAT1 signal activation
Lee et al., Glia 1999
:
These data collectively suggest that in human astrocytes, the p65 homodimer is responsible for ICAM-1 upregulation upon TNF-alpha or IL-1beta stimulation, and that IFN-gamma enhancement of
ICAM-1 involves activation of
STAT-1alpha homodimers