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MYC — VEGFA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Baudino et al., Genes Dev 2002
:
These defects are intrinsic to c-Myc, and are in part associated with a
requirement for
c-Myc for the expression of
vascular endothelial growth factor ( VEGF ), as VEGF can partially rescue these defects
Knies-Bamforth et al., Cancer Res 2004
(Papilloma...) :
In vitro,
c-Myc activation alone was able to induce VEGF protein release and in conjunction with hypoxia, c-Myc activation further
increased VEGF protein
Mezquita et al., Oncogene 2005
:
Myc regulates
VEGF production in B cells by stimulating initiation of VEGF mRNA translation ...
Myc overexpression in avian B cells similarly
resulted in high level
VEGF production ...
Myc stimulates
VEGF production by a rapamycin- and LY294002-sensitive pathway, which does not involve alteration of eIF4E activity
Lasorella et al., Mol Cell Biol 2005
(Neovascularization, Pathologic...) :
In human neuroblastoma, the
N-Myc-driven expression of Id2 is sufficient and
necessary for expression of
VEGF
Mizukami et al., J Biol Chem 2006
(Anoxia...) :
A
role for
c-Myc in the hypoxic induction of
VEGF was demonstrated by site directed mutagenesis of the VEGF promoter and silencing of c-Myc by small interfering RNA
Podar et al., Proc Natl Acad Sci U S A 2006
(Multiple Myeloma...) :
Using siRNA, we confirm the
role of
c-Myc in
VEGF production and secretion, as well as angiogenesis
Song et al., Clin Cancer Res 2009
(Neovascularization, Pathologic...) :
Sp-1 and
c-Myc mediate lysophosphatidic acid induced expression of
vascular endothelial growth factor in ovarian cancer cells via a hypoxia-inducible factor-1 independent mechanism
Dafni et al., Cancer Res 2010
(Neovascularization, Pathologic...) :
This was accompanied by reduced expression of
vascular endothelial growth factor and glutaminase, and is likely
mediated by reduced expression of their transcriptional factors hypoxia-inducible factor-1 and
c-Myc
Tai et al., J Biochem Mol Toxicol 2012
(Colorectal Neoplasms...) :
Upon transient transfection with plasmid encoding siRNA, it was found that expression of c-Myc and
VEGF was significantly downregulated in siRNA transfected cells and the downregulation of
c-Myc and VEGF
inhibited cell growth and induced apoptosis and metastasis of Volo cells