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ELMO2 — RAC1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Brugnera et al., Nat Cell Biol 2002
:
We can also detect a trimeric ELMO1 Dock180
Rac1 complex and
ELMO augments the interaction between Dock180 and Rac ... We can also detect a trimeric ELMO1 Dock180 Rac1 complex and
ELMO augments the interaction between Dock180 and
Rac
Lu et al., Methods Enzymol 2006
:
The best characterized is the
Rac activation by the
Dock180-ELMO complex
Hiramoto et al., Exp Cell Res 2006
:
Dock4 formed a complex with ELMO, and expression of active RhoG induced translocation of the Dock4-ELMO complex from the cytoplasm to the plasma membrane and enhanced the Dock4- and
ELMO dependent
Rac1 activation and cell migration
Tosello-Trampont et al., Cell Death Differ 2007
:
Although the
role of
ELMO : Dock180 in regulating
Rac activation has been well defined, the function of CED-2/CrkII in this complex is less well understood
Yamaki et al., Exp Cell Res 2007
:
However, RhoG induced suppression of anoikis was independent of the
ELMO- and Dock180 mediated
activation of
Rac1
Komander et al., Mol Biol Cell 2008
:
Significantly, although this does not affect DOCK180 GEF activity toward Rac in vivo, Rac signaling is impaired, implying additional
roles for
ELMO in mediating intracellular
Rac signaling
Roppenser et al., J Cell Sci 2009
:
RhoG and its downstream effector module
Elmo/Dock180 controlled both
Rac1 activation by Invasin and Rac1 deactivation by YopE