Gene interactions and pathways from curated databases and text-mining

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CXCR4 — IL2

Text-mined interactions from Literome

Vassiliadou et al., J Immunol 1999 (HIV Infections) : Progesterone treatment had no effect on constitutive expression of CCR5 and CXCR4 by nonactivated T cells and macrophages, but significantly inhibited IL-2 induced up-regulation of CCR5 and CXCR4 on activated T cells ( p < 0.05 )
Pedroza-Martins et al., J Virol 2002 (HIV Infections) : IL-2 and IL-4 together increased expression of CXCR4 and CCR5 in this population, whereas IL-4 and IL-7 increased CXCR4 but not CCR5 expression
Bahr et al., Clin Exp Immunol 2003 (HIV Infections) : Stimulation of MDMs with IL-2 had no measurable effect on HIV-1 replication, on cytokine secretion, or on CD4 and CXCR4 gene expression